CFU-Mast

CFU-Mast (Colony Forming Unit-Mast) is a type of stem cell that is capable of producing mast cells. These cells are a part of the immune system and play a crucial role in the body's defense against pathogens. CFU-Mast cells are derived from hematopoietic stem cells in the bone marrow.

Origin and Development

CFU-Mast cells originate from hematopoietic stem cells in the bone marrow. These stem cells undergo a process of differentiation to become CFU-Mast cells. This process is regulated by various growth factors, including stem cell factor (SCF) and interleukin-3 (IL-3).

Function

The primary function of CFU-Mast cells is to produce mast cells. Mast cells are involved in the immune response, particularly in the defense against pathogens. They release histamine and other inflammatory substances in response to infection or injury, which helps to attract other immune cells to the site of infection or injury.

Clinical Significance

Abnormalities in the number or function of CFU-Mast cells can lead to various health problems. For example, an increase in the number of CFU-Mast cells can lead to mastocytosis, a condition characterized by an excessive number of mast cells in the body. On the other hand, a decrease in the number of CFU-Mast cells can lead to a weakened immune response.

See Also

• Hematopoietic stem cell
• Mast cell
• Immune system
• Mastocytosis

References

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