Apaziquone

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Apaziquone

Apaziquone (pronunciation: /əˈpæzɪkwɒn/) is a bioreductive alkylating agent used in the treatment of non-muscle invasive bladder cancer (NMIBC). It is also known by its trade name, Qapzola.

Etymology

The name "Apaziquone" is derived from the chemical structure of the drug, which belongs to the class of quinones. The prefix "Apa-" is an abbreviation of "alkylating agent", and "-ziquone" is a modification of "quinone".

Mechanism of Action

Apaziquone is activated in the hypoxic environment of cancer cells, where it forms cytotoxic species that can alkylate DNA and proteins, leading to cell death. This mechanism of action is similar to other bioreductive alkylating agents, such as Mitomycin C and Etoposide.

Clinical Use

Apaziquone is used for the treatment of non-muscle invasive bladder cancer (NMIBC) following transurethral resection of bladder tumors (TURBT). It is instilled into the bladder through a catheter, where it can directly act on the cancer cells.

Related Terms

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