Acetoxyacetylaminofluorene

Chemical compound

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Acetoxyacetylaminofluorene is a chemical compound that is primarily studied for its role in biochemical research, particularly in the context of carcinogenesis and mutagenesis. It is a derivative of 2-acetylaminofluorene, a known carcinogen.

Chemical Structure

Acetoxyacetylaminofluorene is characterized by its complex molecular structure, which includes an acetoxy group attached to the acetylaminofluorene moiety. This modification is significant as it influences the compound's biological activity and its interaction with DNA.

Biological Activity

Acetoxyacetylaminofluorene is used in research to study the mechanisms of DNA adduct formation and repair. It is known to form covalent bonds with DNA, leading to mutations that can initiate the process of carcinogenesis. This property makes it a valuable tool in understanding how chemical carcinogens interact with genetic material.

Applications in Research

In laboratory settings, acetoxyacetylaminofluorene is utilized to induce specific types of DNA damage in cell culture and animal models. Researchers use this compound to investigate the efficacy of DNA repair mechanisms and to screen for potential anticancer agents that can mitigate its effects.

Safety and Handling

Due to its carcinogenic potential, acetoxyacetylaminofluorene must be handled with extreme care in a controlled laboratory environment. Proper personal protective equipment (PPE) and safety protocols are essential to minimize exposure and prevent contamination.

Related Compounds

• 2-Acetylaminofluorene
• N-Hydroxy-2-acetylaminofluorene
• [[Benzo[a]pyrene]]

Related pages

• Carcinogen
• Mutagen
• DNA repair
• Chemical safety

Gallery

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  2D structure of Acetoxyacetylaminofluorene
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  3D ball-and-stick model of Acetoxyacetylaminofluorene

Acetoxyacetylaminofluorene

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  Acetoxyacetylaminofluorene
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  Acetoxyacetylaminofluorene 3D Model