5F-ADB-PINACA

5F-ADB-PINACA.svg

5F-ADB-PINACA is a synthetic cannabinoid that has been used as an active ingredient in synthetic cannabis products. It is a potent agonist of the cannabinoid receptors and has been associated with numerous adverse health effects.

Chemical Structure and Properties

5F-ADB-PINACA belongs to the class of indazole-based synthetic cannabinoids. Its chemical structure includes a fluoropentyl chain, which is a common feature in many synthetic cannabinoids. The full chemical name of 5F-ADB-PINACA is N-1-amino-3,3-dimethyl-1-oxobutan-2-yl-1-(5-fluoropentyl)-1H-indazole-3-carboxamide.

Pharmacology

5F-ADB-PINACA acts as a potent agonist at the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including pain sensation, mood, and appetite. The high potency of 5F-ADB-PINACA at these receptors can lead to significant psychoactive effects and potential toxicity.

Health Effects

The use of 5F-ADB-PINACA has been linked to a range of adverse health effects. These can include tachycardia, hypertension, nausea, vomiting, agitation, hallucinations, and seizures. In severe cases, it can lead to acute kidney injury and death.

Legal Status

The legal status of 5F-ADB-PINACA varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and harmful effects. For example, in the United States, it is listed as a Schedule I controlled substance under the Controlled Substances Act.

Detection in Biological Samples

5F-ADB-PINACA can be detected in biological samples using various analytical techniques such as gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). These methods are used in forensic and clinical toxicology to confirm exposure to the substance.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• Controlled Substances Act

References

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