5-MeO-NET
Chemical compound
5-MeO-NET is a chemical compound that belongs to the class of phenethylamines. It is a derivative of the norepinephrine reuptake inhibitor (NRI) class and is structurally related to other compounds such as 5-MeO-DMT and NET.
Chemical Structure and Properties
5-MeO-NET is characterized by the presence of a methoxy group attached to the phenyl ring, which is a common feature in many psychoactive compounds. The chemical structure of 5-MeO-NET can be described as 2-(2-methoxyphenyl)-2-(ethylamino)cyclohexan-1-one. This structure is similar to other compounds in the phenethylamine class, which are known for their psychoactive properties.
Pharmacology
5-MeO-NET acts primarily as a norepinephrine reuptake inhibitor. This means that it increases the concentration of norepinephrine in the synaptic cleft by inhibiting its reabsorption into the presynaptic neuron. Norepinephrine is a neurotransmitter that plays a key role in the regulation of mood, alertness, and stress response. By inhibiting its reuptake, 5-MeO-NET may enhance these effects, although the specific pharmacological profile of 5-MeO-NET in humans is not well-documented.
Potential Effects
The effects of 5-MeO-NET are not well-studied, but based on its mechanism of action, it may produce stimulant-like effects similar to other norepinephrine reuptake inhibitors. These effects could include increased alertness, enhanced mood, and heightened physical energy. However, the lack of comprehensive studies means that the full range of effects and potential side effects are not fully understood.
Legal Status
The legal status of 5-MeO-NET varies by country. In some jurisdictions, it may be classified as a controlled substance due to its structural similarity to other psychoactive compounds. In others, it may not be specifically regulated, although it could still be subject to analog laws that control substances with similar chemical structures and effects.
Research and Development
Research on 5-MeO-NET is limited, and it is not currently known to have any approved medical uses. Most of the interest in this compound comes from the scientific community studying the effects of norepinephrine reuptake inhibitors and their potential applications in treating conditions such as depression and attention deficit hyperactivity disorder (ADHD).
Related Compounds
5-MeO-NET is related to several other compounds in the phenethylamine class, including:
- 5-MeO-DMT - a powerful psychedelic compound.
- NET - a norepinephrine transporter inhibitor.
- Methoxyphenamine - another compound with similar structural features.
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Contributors: Prab R. Tumpati, MD