4-Hydroxyphenylpyruvic acid
An intermediate in the metabolism of the amino acid phenylalanine
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4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. It plays a crucial role in the tyrosine degradation pathway and is involved in several metabolic processes.
Structure and Properties
4-Hydroxyphenylpyruvic acid is a keto acid with the chemical formula C9H8O4. It contains a hydroxy group attached to the phenyl ring, which is characteristic of its structure. The presence of both a carboxylic acid group and a keto group makes it a key intermediate in various biochemical reactions.
Biosynthesis
4-Hydroxyphenylpyruvic acid is synthesized from phenylalanine through a series of enzymatic reactions. The first step involves the conversion of phenylalanine to tyrosine by the enzyme phenylalanine hydroxylase. Tyrosine is then converted to 4-hydroxyphenylpyruvic acid by the enzyme tyrosine aminotransferase.
Metabolic Pathway
In the tyrosine catabolism pathway, 4-hydroxyphenylpyruvic acid is further metabolized to homogentisic acid by the enzyme 4-hydroxyphenylpyruvate dioxygenase. This step is crucial for the breakdown of tyrosine and the production of energy and other metabolites.
Clinical Significance
Deficiencies or malfunctions in the enzymes involved in the metabolism of 4-hydroxyphenylpyruvic acid can lead to metabolic disorders. For example, a deficiency in 4-hydroxyphenylpyruvate dioxygenase can result in tyrosinemia type III, a rare genetic disorder characterized by elevated levels of tyrosine and its metabolites in the blood.
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Related Pages
4-Hydroxyphenylpyruvic acid
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