25I-NB3OMe

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25I-NB3OMe

Chemical structure of 25I-NB3OMe

25I-NB3OMe, also known as 2C-I-NBOMe, is a synthetic psychedelic compound that belongs to the NBOMe class. It is a derivative of the phenethylamine 2C-I and is known for its potent hallucinogenic effects.

Chemical Structure and Properties

25I-NB3OMe is chemically related to the 2C family of phenethylamines, specifically 2C-I. The compound is characterized by the presence of a methoxy group at the 3-position of the benzene ring, which is a modification from the parent compound 2C-I. This modification significantly increases the compound's affinity for the 5-HT2A receptor, which is believed to be responsible for its psychedelic effects.

Pharmacology

The primary mechanism of action for 25I-NB3OMe is its agonistic activity at the 5-HT2A receptor, a subtype of the serotonin receptor that is commonly associated with the effects of classic psychedelics such as LSD and psilocybin. The compound's high potency and efficacy at this receptor make it a powerful hallucinogen, even at low doses.

Effects

Users of 25I-NB3OMe report a range of effects, including visual and auditory hallucinations, altered perception of time, and changes in mood and thought patterns. The intensity and duration of these effects can vary significantly depending on the dose and individual sensitivity.

Risks and Safety

25I-NB3OMe is associated with several risks, particularly due to its high potency. Overdose can lead to severe adverse effects, including vasoconstriction, hypertension, and tachycardia. There have been reports of fatalities associated with the use of NBOMe compounds, often due to misidentification or improper dosing.

Legal Status

The legal status of 25I-NB3OMe varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. Users should be aware of the legal implications of possessing or distributing this compound.

Related Compounds

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Contributors: Prab R. Tumpati, MD