Quinupramine

Tricyclic antidepressant

Quinupramine
INN
Drug class
Routes of administration	Oral
Pregnancy category
Bioavailability
Metabolism	Hepatic
Elimination half-life
Excretion	Renal
Legal status
CAS Number	24881-13-6
PubChem	3047790
DrugBank	DB08998
ChemSpider	2310105
KEGG	D07356

Quinupramine is a tricyclic antidepressant (TCA) that is used in the treatment of depression. It is known for its unique chemical structure and pharmacological properties that distinguish it from other TCAs.

Chemical Structure

Chemical structure of Quinupramine

Quinupramine is characterized by its tricyclic structure, which consists of three interconnected rings. The chemical formula for quinupramine is C₂₀H₂₆N₂. This structure is responsible for its pharmacological activity as a TCA.

Pharmacology

Quinupramine functions primarily by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine, thereby increasing their levels in the synaptic cleft and enhancing neurotransmission. This mechanism is similar to other TCAs, which are known to improve mood and alleviate symptoms of depression.

Clinical Use

Quinupramine is prescribed for the treatment of major depressive disorder. It is administered orally and is metabolized in the liver. The drug is excreted through the kidneys.

Side Effects

As with other tricyclic antidepressants, quinupramine can cause a range of side effects. Common side effects include dry mouth, constipation, urinary retention, and blurred vision. These effects are primarily due to its anticholinergic properties.

Related Pages

• Tricyclic antidepressant
• Depression (mood)
• Serotonin
• Norepinephrine