4-AcO-DET

Synthetic psychedelic compound

4-AcO-DET
INN
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CAS Number	22204-89-3
PubChem	443378
DrugBank
ChemSpider	391558
KEGG

4-Acetoxy-N,N-diethyltryptamine (4-AcO-DET) is a synthetic psychedelic compound belonging to the tryptamine class. It is structurally related to psilocin and psilocybin, which are naturally occurring psychedelic compounds found in certain species of mushrooms.

Chemical Structure and Properties

4-AcO-DET is the acetate ester of 4-HO-DET (4-hydroxy-N,N-diethyltryptamine). Its chemical structure consists of a tryptamine backbone with an acetoxy group at the 4-position of the indole ring. This modification is believed to affect the compound's pharmacokinetics and pharmacodynamics, potentially altering its psychoactive effects compared to its hydroxy counterpart.

Chemical structure of 4-AcO-DET

Pharmacology

4-AcO-DET is thought to act as a prodrug to 4-HO-DET, meaning it is metabolized in the body to produce the active compound. It is believed to exert its effects primarily through the 5-HT2A receptor, similar to other psychedelic tryptamines. The activation of this receptor is associated with the characteristic hallucinogenic effects of psychedelics, including altered perception, mood, and cognition.

Effects

The effects of 4-AcO-DET are reported to be similar to those of other psychedelic tryptamines, such as psilocybin and LSD. Users may experience visual and auditory hallucinations, changes in thought patterns, and an altered sense of time. The intensity and duration of these effects can vary depending on the dose, individual physiology, and environmental factors.

Legal Status

The legal status of 4-AcO-DET varies by country. In some jurisdictions, it is classified as a controlled substance, while in others, it may be unscheduled or fall into a legal gray area. It is important for individuals to be aware of the laws in their region before possessing or using this compound.

History and Research

4-AcO-DET was first synthesized by David E. Nichols and his team in the 1990s as part of their research into psychedelic compounds. Although it has not been extensively studied in humans, it is used in psychedelic research to explore the effects of tryptamines on the brain and consciousness.

Related Compounds

• 4-HO-DET
• 4-AcO-DMT
• 4-HO-DMT
• Psilocybin
• Psilocin

Related Pages

• Psychedelic drug
• Tryptamine
• Serotonin receptor