Memantine

Medication used to treat Alzheimer's disease

Memantine
INN
Drug class
Routes of administration	By mouth
Pregnancy category
Bioavailability	100%
Metabolism	Hepatic (minimal)
Elimination half-life	60–100 hours
Excretion	Renal
Legal status
CAS Number	19982-08-2
PubChem	4054
DrugBank	DB01043
ChemSpider	3914
KEGG	D08270

Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. It is less preferred than acetylcholinesterase inhibitors such as donepezil and rivastigmine. Memantine is taken by mouth.

Medical uses

Memantine is primarily used for the treatment of Alzheimer's disease. It is believed to work by blocking NMDA receptors, which are involved in synaptic plasticity and memory. This action helps to reduce the symptoms of Alzheimer's disease, such as cognitive decline and memory loss.

Side effects

Common side effects of memantine include dizziness, headache, confusion, and constipation. Serious side effects are rare but can include hallucinations, hypertension, and seizures.

Pharmacology

Memantine is an NMDA receptor antagonist. It binds to the NMDA receptor with a higher affinity than magnesium ions, which are naturally present in the synapse. This binding prevents excessive calcium influx into the neuron, which can lead to neuronal damage and cell death.

Pharmacokinetics

Memantine is well absorbed after oral administration, with a bioavailability of nearly 100%. It is minimally metabolized in the liver and is primarily excreted unchanged in the urine. The elimination half-life of memantine is between 60 and 100 hours.

History

Memantine was first synthesized and developed by Eli Lilly and Company in the 1960s. It was later marketed by Merz Pharmaceuticals under the brand name Namenda. It was approved for the treatment of Alzheimer's disease in the United States by the Food and Drug Administration (FDA) in 2003.

Research

Research is ongoing to explore the potential use of memantine in other neurological disorders, such as Parkinson's disease, Huntington's disease, and multiple sclerosis. Studies are also being conducted to investigate its effects on depression and anxiety.

See also

• Alzheimer's disease
• Acetylcholinesterase inhibitors
• NMDA receptor
• Donepezil
• Rivastigmine

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