Glysobuzole
An oral hypoglycemic agent
Glysobuzole is an oral hypoglycemic agent belonging to the class of sulfonylureas. It is used in the management of type 2 diabetes mellitus to help control blood glucose levels.
Mechanism of Action
Glysobuzole works by stimulating the release of insulin from the beta cells of the pancreas. It binds to the sulfonylurea receptor on the beta cell membrane, leading to the closure of ATP-sensitive potassium channels. This results in the depolarization of the beta cell membrane and the opening of voltage-gated calcium channels, allowing calcium influx. The increase in intracellular calcium concentration triggers the exocytosis of insulin-containing granules.
Pharmacokinetics
Glysobuzole is absorbed from the gastrointestinal tract and undergoes hepatic metabolism. It is primarily excreted in the urine. The drug has a half-life that allows for once or twice daily dosing, depending on the formulation and the patient's response.
Clinical Use
Glysobuzole is indicated for the treatment of type 2 diabetes mellitus in patients who are unable to achieve adequate glycemic control with diet and exercise alone. It may be used as monotherapy or in combination with other oral hypoglycemic agents or insulin.
Side Effects
Common side effects of glysobuzole include:
- Hypoglycemia
- Weight gain
- Gastrointestinal disturbances such as nausea and diarrhea
- Allergic reactions
Contraindications
Glysobuzole is contraindicated in patients with:
- Type 1 diabetes mellitus
- Diabetic ketoacidosis
- Severe renal impairment
- Known hypersensitivity to sulfonylureas
Interactions
Glysobuzole may interact with other medications, including:
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