Methylergometrine

A medication used to prevent or control excessive bleeding following childbirth

Methylergometrine
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Methylergometrine, also known as methylergonovine, is a medication used to prevent or control excessive bleeding following childbirth. It is a uterotonic agent that works by increasing the tone, rate, and amplitude of contractions of the smooth muscle of the uterus.

Pharmacology

Methylergometrine is a semisynthetic ergot alkaloid derivative. It acts as a partial agonist on serotonin and dopamine receptors, and as an antagonist on alpha-adrenergic receptors. This action results in the contraction of uterine smooth muscle, which helps to reduce postpartum hemorrhage.

Medical uses

Methylergometrine is primarily used in the management of the third stage of labor and the prevention and treatment of postpartum hemorrhage. It is administered either orally or by injection, depending on the clinical situation.

Side effects

Common side effects of methylergometrine include nausea, vomiting, hypertension, and headache. In rare cases, it can cause seizures or myocardial infarction.

Contraindications

Methylergometrine is contraindicated in patients with hypertension, preeclampsia, or eclampsia. It should also be avoided in patients with a history of coronary artery disease or peripheral vascular disease.

Mechanism of action

Methylergometrine works by stimulating the smooth muscle of the uterus to contract. This is achieved through its action on various receptors, including serotonin receptors and alpha-adrenergic receptors. The increased uterine tone and contractions help to reduce bleeding by compressing the blood vessels in the uterine wall.

Administration

Methylergometrine can be administered orally, intramuscularly, or intravenously. The route of administration depends on the urgency of the situation and the clinical judgment of the healthcare provider.

Related pages

• Postpartum hemorrhage
• Uterotonic
• Ergot alkaloid