7-Nitroindazole

A selective inhibitor of neuronal nitric oxide synthase

7-Nitroindazole
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7-Nitroindazole (7-NI) is a chemical compound that acts as a selective inhibitor of neuronal nitric oxide synthase (nNOS). It is used primarily in scientific research to study the role of nitric oxide in the nervous system.

Chemical Properties

7-Nitroindazole is a derivative of indazole, a bicyclic compound consisting of a benzene ring fused to a pyrazole ring. The addition of a nitro group at the 7-position of the indazole ring confers its selective inhibitory properties.

Mechanism of Action

7-Nitroindazole inhibits the enzyme neuronal nitric oxide synthase (nNOS), which is responsible for the production of nitric oxide (NO) in neurons. Nitric oxide is a signaling molecule involved in various physiological processes, including neurotransmission, vasodilation, and immune response. By inhibiting nNOS, 7-Nitroindazole reduces the production of nitric oxide, allowing researchers to study its effects on the nervous system.

Applications in Research

7-Nitroindazole is used in experimental models to investigate the role of nitric oxide in neurodegenerative diseases, stroke, and pain. It has been shown to have neuroprotective effects in models of ischemia and traumatic brain injury.

Neurodegenerative Diseases

Research has explored the potential of 7-Nitroindazole in conditions such as Parkinson's disease and Alzheimer's disease, where excessive nitric oxide production may contribute to neuronal damage.

Stroke

In models of ischemic stroke, 7-Nitroindazole has been used to assess the impact of reduced nitric oxide production on brain injury and recovery.

Pain Management

7-Nitroindazole has been studied for its effects on nociception and chronic pain, providing insights into the role of nitric oxide in pain pathways.

Safety and Toxicity

While 7-Nitroindazole is a valuable tool in research, its use is primarily limited to laboratory settings. The safety and toxicity profile of 7-Nitroindazole in humans is not well-established, and it is not approved for clinical use.

Related Pages

• Nitric oxide synthase
• Neurotransmitter
• Neuroprotection
• Indazole

Gallery

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  Chemical structure of 7-Nitroindazole