3-MeO-PCE

A dissociative anesthetic drug

3-MeO-PCE
INN
Drug class
Routes of administration	Oral, Insufflation, Intravenous
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status	Uncontrolled
CAS Number	1364933-54-9
PubChem	11905492
DrugBank
ChemSpider	10037792
KEGG

3-Methoxyeticyclidine (3-MeO-PCE) is a dissociative anesthetic of the arylcyclohexylamine class. It is chemically related to phencyclidine (PCP) and 3-MeO-PCP.

Pharmacology

3-MeO-PCE acts primarily as an NMDA receptor antagonist, which leads to its dissociative effects. By inhibiting the NMDA receptor, 3-MeO-PCE disrupts the normal function of the glutamate neurotransmitter system, which is crucial for synaptic plasticity, memory, and learning.

Effects

The effects of 3-MeO-PCE can vary significantly depending on the dose and the individual. Common effects include:

• Dissociation
• Euphoria
• Altered perception of time and space
• Visual and auditory hallucinations
• Analgesia

At higher doses, users may experience more profound dissociation, leading to a state often referred to as "hole" or "K-hole," similar to the effects of ketamine.

Chemistry

3-MeO-PCE is a derivative of eticyclidine (PCE), with a methoxy group attached to the third carbon of the phenyl ring. Its chemical structure is similar to that of 3-MeO-PCP, differing only in the length of the carbon chain attached to the nitrogen atom.

Legal status

The legal status of 3-MeO-PCE varies by country. In some jurisdictions, it is classified as a controlled substance, while in others, it remains unscheduled. Users should be aware of the legal implications of possessing or using 3-MeO-PCE in their region.

Safety and toxicity

The safety profile of 3-MeO-PCE is not well-established, and its use carries potential risks. Users may experience adverse effects such as:

• Nausea
• Vomiting
• Anxiety
• Paranoia
• Psychosis

Long-term use may lead to tolerance, dependence, and potential neurotoxicity.

Related pages

• Phencyclidine
• 3-MeO-PCP
• Ketamine
• Dissociative drug

Gallery

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  Chemical structure of 3-MeO-PCE