Valnemulin

An antibiotic used in veterinary medicine

Valnemulin
File:Valnemulin.svg
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

Valnemulin is a pleuromutilin antibiotic used in veterinary medicine primarily for the treatment of swine and poultry diseases. It is effective against a range of Gram-positive and some Gram-negative bacteria, as well as mycoplasma infections.

Mechanism of action

Valnemulin works by inhibiting bacterial protein synthesis. It binds to the 50S subunit of the bacterial ribosome, thereby preventing the formation of peptide bonds and halting the growth of the bacteria. This mechanism is similar to that of other pleuromutilin antibiotics.

Uses

Valnemulin is primarily used in the treatment of swine dysentery, caused by Brachyspira hyodysenteriae, and enzootic pneumonia in pigs, caused by Mycoplasma hyopneumoniae. It is also used to control necrotic enteritis in poultry, which is caused by Clostridium perfringens.

Administration

Valnemulin is administered orally, often mixed with feed or water, to ensure proper dosage and distribution among livestock. The dosage and duration of treatment depend on the specific disease being treated and the severity of the infection.

Side effects

While generally well-tolerated, valnemulin can cause some side effects in animals, including gastrointestinal disturbances. Overuse or misuse can lead to the development of antibiotic resistance, which is a significant concern in veterinary medicine.

Regulation and approval

Valnemulin is approved for use in many countries, subject to regulations that ensure its safe and effective use in food-producing animals. It is important to adhere to withdrawal periods to ensure that residues do not remain in meat products intended for human consumption.

Related pages

• Pleuromutilin
• Antibiotic resistance
• Veterinary medicine