Butizide

Butizide is a diuretic medication that is often used in combination with other drugs to treat hypertension (high blood pressure). It belongs to the class of medications known as thiazide diuretics, which work by helping the kidneys get rid of excess water and salt.

Pharmacology

Butizide works by inhibiting the sodium-chloride symporter in the distal convoluted tubule of the kidneys. This action prevents the reabsorption of sodium and chloride ions, leading to an increase in the excretion of water and salt. This helps to lower blood pressure and reduce fluid retention.

Clinical Use

Butizide is primarily used in the treatment of hypertension, either alone or in combination with other antihypertensive medications. It may also be used to treat edema (fluid retention) associated with conditions such as congestive heart failure, liver cirrhosis, and renal disease.

Side Effects

Like all medications, Butizide can cause side effects. Common side effects include dizziness, nausea, and headache. Less common but more serious side effects can include electrolyte imbalance, gout, and hypotension (low blood pressure).

Interactions

Butizide can interact with other medications, including digoxin, lithium, and nonsteroidal anti-inflammatory drugs (NSAIDs). These interactions can affect how Butizide works and increase the risk of side effects.

See Also

• Thiazide diuretic
• Hypertension
• Edema

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