Enprostil

Enprostil is a synthetic prostaglandin that is used for the treatment of gastric ulcers. It works by increasing the production of protective mucus in the stomach, which helps to prevent ulcers from forming. Enprostil is also used to prevent ulcers in patients who are taking nonsteroidal anti-inflammatory drugs (NSAIDs), which can cause ulcers.

Mechanism of Action

Enprostil works by mimicking the effects of naturally occurring prostaglandins in the body. Prostaglandins are substances that are produced by the body and have several important functions. They help to protect the lining of the stomach and small intestine from the damaging effects of acid and pepsin, enzymes that break down proteins in the stomach. By increasing the production of mucus and bicarbonate, a substance that neutralizes stomach acid, enprostil helps to protect the stomach lining and prevent ulcers from forming.

Uses

Enprostil is used for the treatment of gastric ulcers and to prevent ulcers in patients who are taking NSAIDs. NSAIDs, such as ibuprofen and aspirin, can cause ulcers by reducing the production of prostaglandins in the stomach. By mimicking the effects of prostaglandins, enprostil helps to protect the stomach lining and prevent ulcers from forming.

Side Effects

Like all medications, enprostil can cause side effects. The most common side effects of enprostil include diarrhea, abdominal pain, and nausea. Less common side effects include headache, dizziness, and rash. If these side effects persist or become bothersome, patients should contact their healthcare provider.

Contraindications

Enprostil should not be used in patients who are allergic to it or to any other prostaglandins. It should also not be used in patients who have a history of inflammatory bowel disease, as it can worsen this condition. Pregnant women should not use enprostil, as it can cause premature labor.

See Also

• Prostaglandin
• Gastric ulcer
• Nonsteroidal anti-inflammatory drug

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