Ticarcillin-clavulanate

Mechanism of action of Ticarcillin-clavulanate

The combination of ticarcillin and clavulanate provides an extended-spectrum penicillin with a beta-lactamase inhibitor and is used to treat serious bacterial infections due to susceptible organisms.

Liver toxicity of Ticarcillin-clavulanate

Given parenterally, ticarcillin-clavulanate can cause mild transient aminotransferase elevations, and therapy has been linked to instances of acute cholestatic liver disease similar to that described commonly with amoxicillin-clavulanate (Augmentin).

Mechanism of action of Ticarcillin-clavulanate

The combination of ticarcillin, a fourth generation penicillin, and clavulanate combines the extended-spectrum of ticarcillin with beta-lactamase inhibitory activity of clavulanic acid.

This combination is indicated for serious infections of the lower respiratory tract, urinary tract, bones and joints and skin. The extended-spectrum of ticarcillin makes it an appropriate agent in therapy of Pseudomonas aeruginosa. Ticarcillin also has extended activity against some Enterobacter and Proteus. Ticarcillin is available only in parenteral formulations.

FDA approval information for Ticarcillin-clavulanate

The combination of ticarcillin and clavulanate was approved for use in the United States in 1985 and is available generically and under the trade name of Timentin.

The combination is provided as 3 grams of ticarcillin with 100 mg of clavulanate which is typically given intravenously every 4 to 6 hours for 5 to 14 days.

Side effects of Ticarcillin-clavulanate

Common side effects of ticarcillin include nausea, epigastric discomfort, diarrhea, headache, dizziness, rash and hypersensitivity reactions.

Penicillin antibiotics

• penicillins first generation (natural penicillins)
  • benzathine penicillin, procaine penicillin, penicillin g, penicillin v, penicillin vk

• penicillins second generation (penicillinase-resistant penicillins)
  • cloxacillin, dicloxacillin, flucloxacillin, methicillin, nafcillin, oxacillin

• penicillins third generation (aminopenicillins)
  • amoxicillin, ampicillin, ampicillin-sulbactam, bacampicillin, pivampicillin
• see also amoxicillin-clavulanate

• penicillins fourth generation (extended-spectrum penicillins)
  • carbenicillin, mezlocillin, piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate

• Dailymed label info on Ticarcillin-clavulanate
• FDA Ticarcillin-clavulanate