Diabetes and deafness

Diabetes and deafness (DAD) or maternally inherited diabetes and deafness (MIDD) is a subtype of diabetes which is caused from a point mutation at position 3243 in human mitochondrial DNA, which is transmitted from the mother and can either present with deafness or diabetes.

Symptoms

The symptoms of DAD are similar to other forms of diabetes, but with the added complication of hearing loss. These symptoms can include:

• Frequent urination
• Excessive thirst
• Unexplained weight loss
• Extreme hunger
• Sudden vision changes
• Tingling or numbness in hands or feet
• Feeling very tired much of the time
• Very dry skin
• Sores that are slow to heal
• More infections than usual

Causes

DAD is caused by a mutation in the mitochondrial DNA, which is only passed on from the mother. This mutation can either present as diabetes or deafness.

Diagnosis

Diagnosis of DAD is based on the clinical symptoms of diabetes and deafness, along with genetic testing to confirm the presence of the mitochondrial mutation.

Treatment

Treatment for DAD is similar to other forms of diabetes, which can include diet and exercise, oral medications, and insulin therapy. The deafness is usually treated with hearing aids.

See also

• Diabetes
• Deafness
• Mitochondrial disease

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