18-Methyltestosterone
Synthetic anabolic steroid
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18-Methyltestosterone is a synthetic anabolic steroid derived from testosterone. It is characterized by the addition of a methyl group at the 18th carbon position of the steroid structure. This modification alters the compound's interaction with the androgen receptor and its metabolic stability.
Chemical Structure
18-Methyltestosterone is a C19 steroid with a methyl group at the 18th carbon. Its chemical structure is similar to that of testosterone, but the additional methyl group provides increased resistance to metabolic degradation, potentially enhancing its anabolic effects.
Pharmacology
The pharmacological effects of 18-Methyltestosterone are primarily mediated through its interaction with the androgen receptor. Like other anabolic steroids, it promotes protein synthesis and muscle growth. The methylation at the 18th position may influence its binding affinity and selectivity for the androgen receptor.
Clinical Use
18-Methyltestosterone has been investigated for its potential use in hormone replacement therapy and the treatment of certain types of breast cancer. However, its clinical applications are limited due to the availability of other anabolic steroids with more favorable safety profiles.
Side Effects
The use of 18-Methyltestosterone, like other anabolic steroids, can lead to a range of side effects. These may include liver toxicity, cardiovascular issues, and endocrine disruption. The methylation at the 18th position may contribute to its hepatotoxic potential.
Synthesis
The synthesis of 18-Methyltestosterone involves the chemical modification of testosterone. The process typically includes the introduction of a methyl group at the 18th carbon position through a series of organic reactions.
Related Compounds
Related Pages
Gallery
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Chemical structure of 18-Methyltestosterone
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