16-Ketoestrone

A metabolite of estrone

16-Ketoestrone is a steroid hormone and a metabolite of estrone, which is one of the three main estrogens produced by the human body. It is part of the estrogen metabolism pathway and plays a role in the biochemistry of hormonal regulation.

Structure and Function

16-Ketoestrone is characterized by the presence of a ketone group at the 16th position of the estrone molecule. This structural modification distinguishes it from other metabolites of estrone, such as estradiol and estriol. The presence of the ketone group influences its biological activity and metabolic pathway.

Biosynthesis

16-Ketoestrone is synthesized from estrone through the action of specific enzymes that catalyze the oxidation of the 16th carbon position. This process is part of the broader steroidogenesis pathway, which involves the conversion of cholesterol into various steroid hormones, including estrogens, androgens, and corticosteroids.

Role in the Body

As a metabolite of estrone, 16-Ketoestrone is involved in the regulation of various physiological processes. Estrogens, including their metabolites, are crucial for the development and maintenance of female reproductive tissues, the regulation of the menstrual cycle, and the maintenance of bone density.

Clinical Significance

The levels of 16-Ketoestrone, along with other estrogen metabolites, can be measured to assess hormonal balance and endocrine function in individuals. Abnormal levels may indicate issues such as hormonal imbalances, menopausal symptoms, or endocrine disorders.

Research and Implications

Research into 16-Ketoestrone and other estrogen metabolites continues to provide insights into their roles in health and disease. Understanding the metabolism of estrogens is important for developing treatments for conditions such as breast cancer, osteoporosis, and cardiovascular disease.

Related Pages

• Estrone
• Estradiol
• Estriol
• Estrogen metabolism
• Steroidogenesis

Gallery

• 
  Structure of 16-Ketoestrone