Metapramine

Antidepressant medication

Metapramine
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

Metapramine is a tricyclic antidepressant (TCA) that is used primarily in the treatment of major depressive disorder. It is known for its efficacy in alleviating symptoms of depression and has been used in clinical settings since its introduction.

Pharmacology

Metapramine functions by inhibiting the reuptake of norepinephrine and serotonin, two neurotransmitters that are believed to play a crucial role in mood regulation. By preventing the reuptake of these neurotransmitters, metapramine increases their availability in the synaptic cleft, thereby enhancing neurotransmission and improving mood.

Mechanism of Action

Metapramine, like other TCAs, works by blocking the serotonin transporter (SERT) and the norepinephrine transporter (NET). This blockade results in increased levels of serotonin and norepinephrine in the brain, which are associated with improved mood and reduced symptoms of depression.

Clinical Use

Metapramine is prescribed for the treatment of major depressive disorder. It is particularly useful in patients who have not responded to other antidepressant medications. The drug is typically administered orally, and the dosage is adjusted based on the patient's response and tolerance.

Side Effects

Common side effects of metapramine include dry mouth, constipation, urinary retention, blurred vision, and sedation. These side effects are typical of tricyclic antidepressants due to their anticholinergic properties. Patients may also experience orthostatic hypotension, which is a drop in blood pressure upon standing.

Contraindications

Metapramine should not be used in patients with a known hypersensitivity to tricyclic antidepressants. It is also contraindicated in individuals with recent myocardial infarction or severe cardiovascular disease. Caution is advised when prescribing metapramine to patients with a history of seizures or bipolar disorder.

Interactions

Metapramine can interact with other medications, leading to potentially serious effects. It should not be used in combination with monoamine oxidase inhibitors (MAOIs) due to the risk of serotonin syndrome. Additionally, caution is advised when used with other central nervous system depressants, as it may enhance their sedative effects.

Related pages

• Tricyclic antidepressant
• Major depressive disorder
• Serotonin
• Norepinephrine