Naegleriasis: Difference between revisions
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{{Infobox medical condition | |||
| name = Naegleriasis | |||
| image = [[File:Méningo-encéphalite_amibienne_primitive.JPG|left|thumb|Naegleriasis]] | |||
| caption = Brain tissue infected with ''[[Naegleria fowleri]]'' | |||
| field = [[Infectious disease]] | |||
| symptoms = [[Headache]], [[fever]], [[nausea]], [[vomiting]], [[stiff neck]], [[seizures]], [[altered mental status]] | |||
| complications = [[Meningoencephalitis]], [[death]] | |||
| onset = 1–9 days after exposure | |||
| duration = Rapid progression, often within 5 days | |||
| causes = ''[[Naegleria fowleri]]'' infection | |||
| risks = Swimming in warm freshwater, use of contaminated water for nasal irrigation | |||
| diagnosis = [[Microscopy]], [[PCR]], [[antigen detection]] | |||
| differential = [[Bacterial meningitis]], [[viral meningitis]], [[encephalitis]] | |||
| prevention = Avoidance of warm freshwater, use of sterile water for nasal irrigation | |||
| treatment = [[Amphotericin B]], [[miltefosine]], [[fluconazole]], [[rifampin]], [[azithromycin]] | |||
| prognosis = Poor, with high mortality rate | |||
| frequency = Rare | |||
}} | |||
[[File:Naegleria fowleri 1040x454.jpg|Naegleriasis|left|thumb]] | |||
[[File:Roman Baths in Bath Spa, England - July 2006.jpg|Naegleriasis|left|thumb]] | |||
'''Naegleriasis''' is a rare and usually fatal brain infection caused by the amoeba ''[[Naegleria fowleri]]''. The amoeba is typically found in warm freshwater environments, such as hot springs and warm lakes. Infection occurs when water containing the amoeba enters the body through the nose. From there, the amoeba travels to the brain where it causes primary amoebic meningoencephalitis (PAM), a brain inflammation that leads to the destruction of brain tissue. | '''Naegleriasis''' is a rare and usually fatal brain infection caused by the amoeba ''[[Naegleria fowleri]]''. The amoeba is typically found in warm freshwater environments, such as hot springs and warm lakes. Infection occurs when water containing the amoeba enters the body through the nose. From there, the amoeba travels to the brain where it causes primary amoebic meningoencephalitis (PAM), a brain inflammation that leads to the destruction of brain tissue. | ||
==Symptoms== | ==Symptoms== | ||
The initial symptoms of naegleriasis may include headache, fever, nausea, or vomiting. Later symptoms can include stiff neck, confusion, lack of attention to people and surroundings, loss of balance, seizures, and hallucinations. After the start of symptoms, the disease progresses rapidly and usually causes death within about 5 days. | The initial symptoms of naegleriasis may include headache, fever, nausea, or vomiting. Later symptoms can include stiff neck, confusion, lack of attention to people and surroundings, loss of balance, seizures, and hallucinations. After the start of symptoms, the disease progresses rapidly and usually causes death within about 5 days. | ||
==Diagnosis== | ==Diagnosis== | ||
[[Diagnosis]] of naegleriasis can be challenging because the disease progresses rapidly, so that diagnosis is often made after death. The disease is diagnosed by detecting ''Naegleria fowleri'' in cerebrospinal fluid (CSF), biopsy, or tissue specimens, or by detecting [[DNA]] of ''Naegleria fowleri'' in CSF or tissue specimens. | [[Diagnosis]] of naegleriasis can be challenging because the disease progresses rapidly, so that diagnosis is often made after death. The disease is diagnosed by detecting ''Naegleria fowleri'' in cerebrospinal fluid (CSF), biopsy, or tissue specimens, or by detecting [[DNA]] of ''Naegleria fowleri'' in CSF or tissue specimens. | ||
==Treatment== | ==Treatment== | ||
[[Treatment]] for naegleriasis generally involves a combination of several drugs, including an antifungal drug called [[amphotericin B]], which can be effective against ''Naegleria fowleri''. However, even with treatment, the disease is usually fatal. | [[Treatment]] for naegleriasis generally involves a combination of several drugs, including an antifungal drug called [[amphotericin B]], which can be effective against ''Naegleria fowleri''. However, even with treatment, the disease is usually fatal. | ||
==Prevention== | ==Prevention== | ||
[[Prevention]] of naegleriasis involves avoiding warm freshwater environments or using nose clips when swimming or diving in such environments. It is also important to avoid disturbing the sediment while swimming in shallow, warm freshwater areas. | [[Prevention]] of naegleriasis involves avoiding warm freshwater environments or using nose clips when swimming or diving in such environments. It is also important to avoid disturbing the sediment while swimming in shallow, warm freshwater areas. | ||
==See also== | ==See also== | ||
* [[Amoebiasis]] | * [[Amoebiasis]] | ||
* [[Meningoencephalitis]] | * [[Meningoencephalitis]] | ||
* [[Parasitic diseases]] | * [[Parasitic diseases]] | ||
[[Category:Infectious diseases]] | [[Category:Infectious diseases]] | ||
[[Category:Parasitic diseases]] | [[Category:Parasitic diseases]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 22:11, 9 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD's medical weight loss NYC, sleep center NYC
Philadelphia medical weight loss and Philadelphia sleep clinics
| Naegleriasis | |
|---|---|
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Headache, fever, nausea, vomiting, stiff neck, seizures, altered mental status |
| Complications | Meningoencephalitis, death |
| Onset | 1–9 days after exposure |
| Duration | Rapid progression, often within 5 days |
| Types | N/A |
| Causes | Naegleria fowleri infection |
| Risks | Swimming in warm freshwater, use of contaminated water for nasal irrigation |
| Diagnosis | Microscopy, PCR, antigen detection |
| Differential diagnosis | Bacterial meningitis, viral meningitis, encephalitis |
| Prevention | Avoidance of warm freshwater, use of sterile water for nasal irrigation |
| Treatment | Amphotericin B, miltefosine, fluconazole, rifampin, azithromycin |
| Medication | N/A |
| Prognosis | Poor, with high mortality rate |
| Frequency | Rare |
| Deaths | N/A |
Naegleriasis is a rare and usually fatal brain infection caused by the amoeba Naegleria fowleri. The amoeba is typically found in warm freshwater environments, such as hot springs and warm lakes. Infection occurs when water containing the amoeba enters the body through the nose. From there, the amoeba travels to the brain where it causes primary amoebic meningoencephalitis (PAM), a brain inflammation that leads to the destruction of brain tissue.
Symptoms[edit]
The initial symptoms of naegleriasis may include headache, fever, nausea, or vomiting. Later symptoms can include stiff neck, confusion, lack of attention to people and surroundings, loss of balance, seizures, and hallucinations. After the start of symptoms, the disease progresses rapidly and usually causes death within about 5 days.
Diagnosis[edit]
Diagnosis of naegleriasis can be challenging because the disease progresses rapidly, so that diagnosis is often made after death. The disease is diagnosed by detecting Naegleria fowleri in cerebrospinal fluid (CSF), biopsy, or tissue specimens, or by detecting DNA of Naegleria fowleri in CSF or tissue specimens.
Treatment[edit]
Treatment for naegleriasis generally involves a combination of several drugs, including an antifungal drug called amphotericin B, which can be effective against Naegleria fowleri. However, even with treatment, the disease is usually fatal.
Prevention[edit]
Prevention of naegleriasis involves avoiding warm freshwater environments or using nose clips when swimming or diving in such environments. It is also important to avoid disturbing the sediment while swimming in shallow, warm freshwater areas.
