Pustulosis palmaris et plantaris: Difference between revisions
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{{Infobox medical condition | |||
| name = Pustulosis palmaris et plantaris | |||
| image = [[File:Pustular_Psoriasis.jpg|left|thumb|Pustulosis palmaris et plantaris]] | |||
| caption = Pustulosis palmaris et plantaris affecting the palms and soles | |||
| synonyms = Palmoplantar pustulosis | |||
| specialty = [[Dermatology]] | |||
| symptoms = [[Pustules]] on palms and soles, [[erythema]], [[scaling]] | |||
| complications = [[Psoriatic arthritis]], [[nail changes]] | |||
| onset = Typically in [[adulthood]] | |||
| duration = [[Chronic condition|Chronic]] | |||
| causes = Unknown, possibly [[autoimmune]] | |||
| risks = [[Smoking]], [[stress]], [[genetic predisposition]] | |||
| diagnosis = [[Clinical diagnosis]], [[skin biopsy]] | |||
| differential = [[Psoriasis]], [[dyshidrotic eczema]], [[tinea]] | |||
| treatment = [[Topical corticosteroids]], [[phototherapy]], [[systemic therapy]] | |||
| medication = [[Acitretin]], [[methotrexate]], [[cyclosporine]] | |||
| frequency = Rare | |||
}} | |||
{{Short description|A chronic skin condition affecting the palms and soles}} | {{Short description|A chronic skin condition affecting the palms and soles}} | ||
'''Pustulosis palmaris et plantaris''' is a chronic inflammatory skin condition characterized by the presence of pustules on the palms of the hands and the soles of the feet. It is considered a variant of [[psoriasis]] and is sometimes referred to as palmoplantar pustulosis. | '''Pustulosis palmaris et plantaris''' is a chronic inflammatory skin condition characterized by the presence of pustules on the palms of the hands and the soles of the feet. It is considered a variant of [[psoriasis]] and is sometimes referred to as palmoplantar pustulosis. | ||
==Clinical Presentation== | ==Clinical Presentation== | ||
Pustulosis palmaris et plantaris primarily affects the [[palms]] and [[soles]], presenting with sterile pustules that can coalesce into larger areas of pus-filled blisters. These pustules are often accompanied by erythema (redness) and scaling. The condition can be painful and may significantly impact a patient's quality of life due to discomfort and the potential for secondary [[infection]]. | Pustulosis palmaris et plantaris primarily affects the [[palms]] and [[soles]], presenting with sterile pustules that can coalesce into larger areas of pus-filled blisters. These pustules are often accompanied by erythema (redness) and scaling. The condition can be painful and may significantly impact a patient's quality of life due to discomfort and the potential for secondary [[infection]]. | ||
==Pathophysiology== | ==Pathophysiology== | ||
The exact cause of pustulosis palmaris et plantaris is not fully understood, but it is believed to be an autoimmune disorder. The condition is associated with an abnormal immune response that leads to the accumulation of neutrophils in the epidermis, resulting in pustule formation. Genetic factors, environmental triggers, and lifestyle factors such as smoking have been implicated in the development and exacerbation of the disease. | The exact cause of pustulosis palmaris et plantaris is not fully understood, but it is believed to be an autoimmune disorder. The condition is associated with an abnormal immune response that leads to the accumulation of neutrophils in the epidermis, resulting in pustule formation. Genetic factors, environmental triggers, and lifestyle factors such as smoking have been implicated in the development and exacerbation of the disease. | ||
==Diagnosis== | ==Diagnosis== | ||
Diagnosis of pustulosis palmaris et plantaris is primarily clinical, based on the characteristic appearance of the pustules on the palms and soles. A [[skin biopsy]] may be performed to rule out other conditions and to confirm the diagnosis by demonstrating the presence of neutrophils in the epidermis. | Diagnosis of pustulosis palmaris et plantaris is primarily clinical, based on the characteristic appearance of the pustules on the palms and soles. A [[skin biopsy]] may be performed to rule out other conditions and to confirm the diagnosis by demonstrating the presence of neutrophils in the epidermis. | ||
==Treatment== | ==Treatment== | ||
Treatment of pustulosis palmaris et plantaris can be challenging and often requires a combination of therapies. Topical treatments such as corticosteroids and vitamin D analogs are commonly used to reduce inflammation and promote healing. In more severe cases, systemic treatments such as [[methotrexate]], [[cyclosporine]], or biologic agents may be necessary. Phototherapy is another option that can be effective for some patients. | Treatment of pustulosis palmaris et plantaris can be challenging and often requires a combination of therapies. Topical treatments such as corticosteroids and vitamin D analogs are commonly used to reduce inflammation and promote healing. In more severe cases, systemic treatments such as [[methotrexate]], [[cyclosporine]], or biologic agents may be necessary. Phototherapy is another option that can be effective for some patients. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for pustulosis palmaris et plantaris varies. While some patients may experience periods of remission, others may have chronic, persistent symptoms. The condition can be difficult to manage, and ongoing treatment is often required to control symptoms and prevent flare-ups. | The prognosis for pustulosis palmaris et plantaris varies. While some patients may experience periods of remission, others may have chronic, persistent symptoms. The condition can be difficult to manage, and ongoing treatment is often required to control symptoms and prevent flare-ups. | ||
==See also== | |||
== | |||
* [[Psoriasis]] | * [[Psoriasis]] | ||
* [[Autoimmune disease]] | * [[Autoimmune disease]] | ||
* [[Dermatology]] | * [[Dermatology]] | ||
* [[Skin biopsy]] | * [[Skin biopsy]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
[[Category:Skin conditions]] | [[Category:Skin conditions]] | ||
Latest revision as of 06:00, 8 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Pustulosis palmaris et plantaris | |
|---|---|
 | |
| Synonyms | Palmoplantar pustulosis |
| Pronounce | N/A |
| Specialty | Dermatology |
| Symptoms | Pustules on palms and soles, erythema, scaling |
| Complications | Psoriatic arthritis, nail changes |
| Onset | Typically in adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Unknown, possibly autoimmune |
| Risks | Smoking, stress, genetic predisposition |
| Diagnosis | Clinical diagnosis, skin biopsy |
| Differential diagnosis | Psoriasis, dyshidrotic eczema, tinea |
| Prevention | N/A |
| Treatment | Topical corticosteroids, phototherapy, systemic therapy |
| Medication | Acitretin, methotrexate, cyclosporine |
| Prognosis | N/A |
| Frequency | Rare |
| Deaths | N/A |
A chronic skin condition affecting the palms and soles
Pustulosis palmaris et plantaris is a chronic inflammatory skin condition characterized by the presence of pustules on the palms of the hands and the soles of the feet. It is considered a variant of psoriasis and is sometimes referred to as palmoplantar pustulosis.
Clinical Presentation[edit]
Pustulosis palmaris et plantaris primarily affects the palms and soles, presenting with sterile pustules that can coalesce into larger areas of pus-filled blisters. These pustules are often accompanied by erythema (redness) and scaling. The condition can be painful and may significantly impact a patient's quality of life due to discomfort and the potential for secondary infection.
Pathophysiology[edit]
The exact cause of pustulosis palmaris et plantaris is not fully understood, but it is believed to be an autoimmune disorder. The condition is associated with an abnormal immune response that leads to the accumulation of neutrophils in the epidermis, resulting in pustule formation. Genetic factors, environmental triggers, and lifestyle factors such as smoking have been implicated in the development and exacerbation of the disease.
Diagnosis[edit]
Diagnosis of pustulosis palmaris et plantaris is primarily clinical, based on the characteristic appearance of the pustules on the palms and soles. A skin biopsy may be performed to rule out other conditions and to confirm the diagnosis by demonstrating the presence of neutrophils in the epidermis.
Treatment[edit]
Treatment of pustulosis palmaris et plantaris can be challenging and often requires a combination of therapies. Topical treatments such as corticosteroids and vitamin D analogs are commonly used to reduce inflammation and promote healing. In more severe cases, systemic treatments such as methotrexate, cyclosporine, or biologic agents may be necessary. Phototherapy is another option that can be effective for some patients.
Prognosis[edit]
The prognosis for pustulosis palmaris et plantaris varies. While some patients may experience periods of remission, others may have chronic, persistent symptoms. The condition can be difficult to manage, and ongoing treatment is often required to control symptoms and prevent flare-ups.
