Generalized pustular psoriasis: Difference between revisions
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{{Infobox medical condition | |||
| name = Generalized pustular psoriasis | |||
| synonyms = Von Zumbusch psoriasis | |||
| field = [[Dermatology]] | |||
| symptoms = [[Pustule]]s, [[erythema]], [[fever]], [[malaise]] | |||
| complications = [[Sepsis]], [[liver failure]], [[heart failure]] | |||
| onset = Can occur at any age | |||
| duration = Chronic, with acute flares | |||
| causes = [[Genetic]] factors, [[immune system]] dysregulation | |||
| risks = [[Psoriasis]], [[infection]], [[stress]], [[pregnancy]] | |||
| diagnosis = [[Clinical diagnosis]], [[skin biopsy]] | |||
| differential = [[Impetigo]], [[acute generalized exanthematous pustulosis]], [[subcorneal pustular dermatosis]] | |||
| treatment = [[Topical corticosteroids]], [[systemic therapy]] (e.g., [[methotrexate]], [[cyclosporine]], [[biologics]]) | |||
| medication = [[Acitretin]], [[infliximab]], [[etanercept]] | |||
| prognosis = Variable, can be life-threatening if untreated | |||
| frequency = Rare | |||
}} | |||
'''Generalized pustular psoriasis''' ('''GPP''') is a rare, severe form of [[psoriasis]] that is characterized by widespread [[pustules]], high fever, and systemic symptoms. It can occur with or without previous psoriasis conditions or history. | '''Generalized pustular psoriasis''' ('''GPP''') is a rare, severe form of [[psoriasis]] that is characterized by widespread [[pustules]], high fever, and systemic symptoms. It can occur with or without previous psoriasis conditions or history. | ||
== Symptoms == | == Symptoms == | ||
The primary symptom of GPP is the sudden onset of widespread, coalescent pustules. These are not infectious, but they are painful and can cause significant discomfort. Other symptoms can include: | The primary symptom of GPP is the sudden onset of widespread, coalescent pustules. These are not infectious, but they are painful and can cause significant discomfort. Other symptoms can include: | ||
* [[Fever]] | * [[Fever]] | ||
* [[Fatigue]] | * [[Fatigue]] | ||
| Line 10: | Line 26: | ||
* [[Muscle weakness]] | * [[Muscle weakness]] | ||
* [[Rapid pulse]] | * [[Rapid pulse]] | ||
== Causes == | == Causes == | ||
The exact cause of GPP is unknown, but it is believed to be an autoinflammatory disease, which means it is caused by a malfunctioning immune system. It can be triggered by various factors, including: | The exact cause of GPP is unknown, but it is believed to be an autoinflammatory disease, which means it is caused by a malfunctioning immune system. It can be triggered by various factors, including: | ||
* [[Infections]] | * [[Infections]] | ||
* [[Stress]] | * [[Stress]] | ||
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* [[Pregnancy]] | * [[Pregnancy]] | ||
* [[Menstruation]] | * [[Menstruation]] | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of GPP is based on the clinical presentation and the exclusion of other conditions. A skin biopsy may be performed to confirm the diagnosis. | Diagnosis of GPP is based on the clinical presentation and the exclusion of other conditions. A skin biopsy may be performed to confirm the diagnosis. | ||
== Treatment == | == Treatment == | ||
Treatment of GPP is aimed at managing the symptoms and preventing complications. This can include: | Treatment of GPP is aimed at managing the symptoms and preventing complications. This can include: | ||
* [[Topical treatments]] | * [[Topical treatments]] | ||
* [[Systemic medications]] | * [[Systemic medications]] | ||
* [[Phototherapy]] | * [[Phototherapy]] | ||
* [[Biologic therapies]] | * [[Biologic therapies]] | ||
== Prognosis == | == Prognosis == | ||
The prognosis for GPP varies. Some people may experience a single episode and never have another, while others may have recurring episodes. It can be life-threatening if not treated promptly and appropriately. | The prognosis for GPP varies. Some people may experience a single episode and never have another, while others may have recurring episodes. It can be life-threatening if not treated promptly and appropriately. | ||
== See also == | == See also == | ||
* [[Psoriasis]] | * [[Psoriasis]] | ||
* [[Pustular psoriasis]] | * [[Pustular psoriasis]] | ||
* [[Autoinflammatory diseases]] | * [[Autoinflammatory diseases]] | ||
== References == | == References == | ||
<references /> | <references /> | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Autoinflammatory diseases]] | [[Category:Autoinflammatory diseases]] | ||
[[Category:Psoriasis]] | [[Category:Psoriasis]] | ||
{{stub}} | {{stub}} | ||
{{No image}} | {{No image}} | ||
Latest revision as of 04:03, 4 April 2025
| Generalized pustular psoriasis | |
|---|---|
| Synonyms | Von Zumbusch psoriasis |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Pustules, erythema, fever, malaise |
| Complications | Sepsis, liver failure, heart failure |
| Onset | Can occur at any age |
| Duration | Chronic, with acute flares |
| Types | N/A |
| Causes | Genetic factors, immune system dysregulation |
| Risks | Psoriasis, infection, stress, pregnancy |
| Diagnosis | Clinical diagnosis, skin biopsy |
| Differential diagnosis | Impetigo, acute generalized exanthematous pustulosis, subcorneal pustular dermatosis |
| Prevention | N/A |
| Treatment | Topical corticosteroids, systemic therapy (e.g., methotrexate, cyclosporine, biologics) |
| Medication | Acitretin, infliximab, etanercept |
| Prognosis | Variable, can be life-threatening if untreated |
| Frequency | Rare |
| Deaths | N/A |
Generalized pustular psoriasis (GPP) is a rare, severe form of psoriasis that is characterized by widespread pustules, high fever, and systemic symptoms. It can occur with or without previous psoriasis conditions or history.
Symptoms[edit]
The primary symptom of GPP is the sudden onset of widespread, coalescent pustules. These are not infectious, but they are painful and can cause significant discomfort. Other symptoms can include:
Causes[edit]
The exact cause of GPP is unknown, but it is believed to be an autoinflammatory disease, which means it is caused by a malfunctioning immune system. It can be triggered by various factors, including:
Diagnosis[edit]
Diagnosis of GPP is based on the clinical presentation and the exclusion of other conditions. A skin biopsy may be performed to confirm the diagnosis.
Treatment[edit]
Treatment of GPP is aimed at managing the symptoms and preventing complications. This can include:
Prognosis[edit]
The prognosis for GPP varies. Some people may experience a single episode and never have another, while others may have recurring episodes. It can be life-threatening if not treated promptly and appropriately.
See also[edit]
References[edit]
<references />
