Pustular psoriasis

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC

Pustular psoriasis
Pustular psoriasis on the hand
Synonyms
Pronounce	N/A
Specialty	N/A
Symptoms	Redness, scaling, pustules
Complications	Secondary infection, erythroderma
Onset	Any age, often in adulthood
Duration	Chronic
Types	N/A
Causes	Genetic factors, immune system dysfunction
Risks	Smoking, stress, infection, pregnancy
Diagnosis	Clinical examination, skin biopsy
Differential diagnosis	Impetigo, dermatitis, fungal infection
Prevention	N/A
Treatment	Topical corticosteroids, systemic therapy, biologics
Medication	Methotrexate, cyclosporine, acitretin
Prognosis	N/A
Frequency	Rare
Deaths	Rarely life-threatening

A type of psoriasis characterized by pustules

Pustular psoriasis is a rare form of psoriasis characterized by the presence of pustules, or small blisters filled with non-infectious pus, on the skin. This condition can be localized or generalized and is often accompanied by systemic symptoms such as fever and malaise.

Types

Pustular psoriasis can be classified into several types based on the distribution and severity of the pustules:

Generalized pustular psoriasis

Generalized pustular psoriasis (GPP), also known as von Zumbusch psoriasis, is a severe form that can cover large areas of the body. It is often associated with systemic symptoms such as fever, chills, and fatigue. GPP can be life-threatening and requires immediate medical attention.

Localized pustular psoriasis

Localized pustular psoriasis includes:

• Palmoplantar pustulosis: This type affects the palms of the hands and the soles of the feet. It is characterized by the presence of pustules and scaling in these areas.
• Acrodermatitis continua of Hallopeau: This rare form affects the tips of the fingers and toes, often leading to nail changes and loss.

Pathophysiology

The exact cause of pustular psoriasis is not fully understood, but it is believed to involve a combination of genetic, immune, and environmental factors. The condition is thought to result from an abnormal immune response that leads to the rapid turnover of skin cells and the formation of pustules.

Symptoms

The primary symptom of pustular psoriasis is the appearance of pustules on the skin. These pustules are typically surrounded by red, inflamed skin and may be accompanied by:

• Fever
• Chills
• Fatigue
• Muscle weakness

Diagnosis

Diagnosis of pustular psoriasis is based on clinical examination and the characteristic appearance of the pustules. A skin biopsy may be performed to confirm the diagnosis and rule out other conditions.

Treatment

Treatment of pustular psoriasis depends on the severity and extent of the disease. Options include:

• Topical treatments such as corticosteroids and vitamin D analogs
• Systemic treatments including retinoids, methotrexate, and cyclosporine
• Biologic therapies targeting specific immune pathways
• Phototherapy

Prognosis

The prognosis for pustular psoriasis varies depending on the type and severity of the condition. While localized forms may be managed effectively with treatment, generalized pustular psoriasis can be life-threatening and requires aggressive management.

See also

• Psoriasis
• Dermatology
• Autoimmune disease