Massive perivillous fibrin deposition: Difference between revisions
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{{Infobox medical condition | |||
| name = Massive perivillous fibrin deposition | |||
| synonyms = Maternal floor infarction | |||
| field = [[Obstetrics]], [[Pathology]] | |||
| symptoms = [[Intrauterine growth restriction]], [[Stillbirth]], [[Recurrent miscarriage]] | |||
| complications = [[Fetal death]], [[Placental insufficiency]] | |||
| onset = [[Pregnancy]] | |||
| duration = [[Chronic]] | |||
| causes = Unknown, possibly [[immune-mediated]] | |||
| risks = [[Previous pregnancy complications]], [[Autoimmune disorders]] | |||
| diagnosis = [[Histopathology]] of the [[placenta]] | |||
| differential = [[Placental abruption]], [[Chorioamnionitis]] | |||
| prevention = None known | |||
| treatment = [[Close monitoring]], [[Aspirin therapy]], [[Heparin therapy]] | |||
| prognosis = Variable, depends on severity and management | |||
| frequency = Rare | |||
}} | |||
'''Massive Perivillous Fibrin Deposition''' (MPFD) is a rare placental disorder characterized by the extensive accumulation of [[fibrin]] on the [[chorionic villi]] of the [[placenta]]. This condition is associated with adverse pregnancy outcomes, including [[fetal growth restriction]], [[stillbirth]], and recurrent [[miscarriage]]. | '''Massive Perivillous Fibrin Deposition''' (MPFD) is a rare placental disorder characterized by the extensive accumulation of [[fibrin]] on the [[chorionic villi]] of the [[placenta]]. This condition is associated with adverse pregnancy outcomes, including [[fetal growth restriction]], [[stillbirth]], and recurrent [[miscarriage]]. | ||
==Etiology== | ==Etiology== | ||
The exact cause of MPFD is unknown. However, it is believed to be associated with maternal [[autoimmune disorders]], [[thrombophilia]], and [[infections]]. Some studies suggest that MPFD may be a response to maternal-fetal [[immune]] conflict. | The exact cause of MPFD is unknown. However, it is believed to be associated with maternal [[autoimmune disorders]], [[thrombophilia]], and [[infections]]. Some studies suggest that MPFD may be a response to maternal-fetal [[immune]] conflict. | ||
==Pathophysiology== | ==Pathophysiology== | ||
In MPFD, there is an excessive deposition of fibrin, a protein involved in blood clotting, on the chorionic villi of the placenta. This leads to impaired [[maternal-fetal circulation]], resulting in reduced nutrient and oxygen supply to the fetus. The condition can lead to fetal growth restriction, stillbirth, or recurrent miscarriage. | In MPFD, there is an excessive deposition of fibrin, a protein involved in blood clotting, on the chorionic villi of the placenta. This leads to impaired [[maternal-fetal circulation]], resulting in reduced nutrient and oxygen supply to the fetus. The condition can lead to fetal growth restriction, stillbirth, or recurrent miscarriage. | ||
==Diagnosis== | ==Diagnosis== | ||
Diagnosis of MPFD is usually made postpartum by histopathological examination of the placenta. Prenatal diagnosis is challenging due to the lack of specific clinical features and imaging findings. | Diagnosis of MPFD is usually made postpartum by histopathological examination of the placenta. Prenatal diagnosis is challenging due to the lack of specific clinical features and imaging findings. | ||
==Treatment== | ==Treatment== | ||
There is no specific treatment for MPFD. Management is usually supportive and aimed at addressing the associated complications. In some cases, anticoagulant therapy may be considered. | There is no specific treatment for MPFD. Management is usually supportive and aimed at addressing the associated complications. In some cases, anticoagulant therapy may be considered. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis of MPFD is generally poor, with a high rate of recurrence in subsequent pregnancies. However, with close monitoring and appropriate management, some women with MPFD may have successful pregnancies. | The prognosis of MPFD is generally poor, with a high rate of recurrence in subsequent pregnancies. However, with close monitoring and appropriate management, some women with MPFD may have successful pregnancies. | ||
==See also== | ==See also== | ||
* [[Placenta]] | * [[Placenta]] | ||
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* [[Thrombophilia]] | * [[Thrombophilia]] | ||
* [[Infections]] | * [[Infections]] | ||
[[Category:Obstetrics]] | [[Category:Obstetrics]] | ||
[[Category:Pathology]] | [[Category:Pathology]] | ||
[[Category:Placental disorders]] | [[Category:Placental disorders]] | ||
{{stub}} | {{stub}} | ||
{{No image}} | {{No image}} | ||
Latest revision as of 01:50, 4 April 2025
| Massive perivillous fibrin deposition | |
|---|---|
| Synonyms | Maternal floor infarction |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Intrauterine growth restriction, Stillbirth, Recurrent miscarriage |
| Complications | Fetal death, Placental insufficiency |
| Onset | Pregnancy |
| Duration | Chronic |
| Types | N/A |
| Causes | Unknown, possibly immune-mediated |
| Risks | Previous pregnancy complications, Autoimmune disorders |
| Diagnosis | Histopathology of the placenta |
| Differential diagnosis | Placental abruption, Chorioamnionitis |
| Prevention | None known |
| Treatment | Close monitoring, Aspirin therapy, Heparin therapy |
| Medication | N/A |
| Prognosis | Variable, depends on severity and management |
| Frequency | Rare |
| Deaths | N/A |
Massive Perivillous Fibrin Deposition (MPFD) is a rare placental disorder characterized by the extensive accumulation of fibrin on the chorionic villi of the placenta. This condition is associated with adverse pregnancy outcomes, including fetal growth restriction, stillbirth, and recurrent miscarriage.
Etiology[edit]
The exact cause of MPFD is unknown. However, it is believed to be associated with maternal autoimmune disorders, thrombophilia, and infections. Some studies suggest that MPFD may be a response to maternal-fetal immune conflict.
Pathophysiology[edit]
In MPFD, there is an excessive deposition of fibrin, a protein involved in blood clotting, on the chorionic villi of the placenta. This leads to impaired maternal-fetal circulation, resulting in reduced nutrient and oxygen supply to the fetus. The condition can lead to fetal growth restriction, stillbirth, or recurrent miscarriage.
Diagnosis[edit]
Diagnosis of MPFD is usually made postpartum by histopathological examination of the placenta. Prenatal diagnosis is challenging due to the lack of specific clinical features and imaging findings.
Treatment[edit]
There is no specific treatment for MPFD. Management is usually supportive and aimed at addressing the associated complications. In some cases, anticoagulant therapy may be considered.
Prognosis[edit]
The prognosis of MPFD is generally poor, with a high rate of recurrence in subsequent pregnancies. However, with close monitoring and appropriate management, some women with MPFD may have successful pregnancies.
