PSB-10: Difference between revisions

Latest revision as of 19:13, 22 March 2025

A chemical compound used in scientific research

PSB-10 is a chemical compound that has been studied for its potential effects on various biological systems. It is primarily used in scientific research to explore its interactions with specific receptors and enzymes in the body. PSB-10 is of interest in the field of pharmacology due to its potential applications in understanding neurotransmitter systems and developing new therapeutic agents.

Chemical Structure and Properties[edit]

PSB-10 is classified as a small molecule with a specific chemical structure that allows it to interact with biological targets. The molecular formula of PSB-10 is C₁₈H₁₉ClN₄O₂, and it has a molecular weight of approximately 358.82 g/mol. The compound contains a chlorine atom, which is often involved in the modulation of its biological activity.

Mechanism of Action[edit]

PSB-10 is known to act as an antagonist at certain adenosine receptors, particularly the A_2A receptor. Adenosine receptors are a class of G protein-coupled receptors that play a crucial role in various physiological processes, including cardiovascular function, immune response, and neurotransmission. By blocking these receptors, PSB-10 can influence the signaling pathways that are normally activated by the endogenous ligand, adenosine.

Research Applications[edit]

In scientific research, PSB-10 is used to study the role of adenosine receptors in different biological systems. It is particularly valuable in neuroscience research, where it helps to elucidate the function of adenosine in the central nervous system. Researchers use PSB-10 to investigate its potential effects on cognition, memory, and neuroprotection.

Potential Therapeutic Uses[edit]

While PSB-10 is primarily a research tool, its ability to modulate adenosine receptors suggests potential therapeutic applications. Compounds like PSB-10 could be developed into drugs for treating conditions such as Parkinson's disease, chronic pain, and inflammatory disorders. However, further research is needed to fully understand its efficacy and safety in clinical settings.

Safety and Toxicology[edit]

As with many research chemicals, the safety profile of PSB-10 is not fully established. It is important for researchers to handle the compound with care and follow appropriate safety protocols. Toxicological studies are necessary to determine its potential effects on human health.

Related Pages[edit]

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-[[File:PSB-10.svg|PSB-10|thumb]]
+{{Short description|A chemical compound used in scientific research}}
+{{DISPLAYTITLE:PSB-10}}
-'''PSB-10''' is a drug which acts as a selective [[antagonist]]<ref name="pmid12517430">{{cite journal | author = Ozola V, Thorand M, Diekmann M, Qurishi R, Schumacher B, Jacobson KA, Müller CE. | title = 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at Human A3 adenosine receptors | journal = Bioorg Med Chem. | volume = 11 | issue = 3 | pages = 347-56 | year = 2003 | pmid = 12517430 | doi = 10.1016/S0968-0896(02)00456-X | url = | issn = }}</ref> for the [[adenosine]] [[Adenosine A3 receptor|A<sub>3</sub>]] [[Receptor (biochemistry)|receptor]] (k<sub>i</sub> value at human A<sub>3</sub> receptor is 0.44 nM), with high selectivity over the other three [[adenosine receptor]] subtypes (k<sub>i</sub> values at human A<sub>1</sub>, A<sub>2A</sub> and A<sub>2B</sub> receptors are 4.1, 3.3 and 30 µM). Further pharmacological experiments in a [<sup>35</sup>S]GTPγS binding assay using hA<sub>3</sub>-CHO-cells indicated that PSB-10 acts as an inverse agonist (IC<sub>50</sub> = 4 nM).
+'''PSB-10''' is a chemical compound that has been studied for its potential effects on various biological systems. It is primarily used in scientific research to explore its interactions with specific [[receptor]]s and [[enzyme]]s in the body. PSB-10 is of interest in the field of [[pharmacology]] due to its potential applications in understanding [[neurotransmitter]] systems and developing new therapeutic agents.
-It has been shown to produce [[antiinflammatory]] effects in animal studies.<ref name="pmid18188542">{{cite journal | author = Bilkei-Gorzo A, Abo-Salem OM, Hayallah AM, Michel K, Müller CE, Zimmer A | title = Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia | journal = Naunyn-Schmiedeberg's Archives of Pharmacology | volume = 377 | issue = 1 | pages = 65–76 |date=March 2008 | pmid = 18188542 | doi = 10.1007/s00210-007-0252-9 | url = | issn = }}</ref> Simple [[xanthine]] derivatives such as [[caffeine]] and [[8-Cyclopentyl-1,3-dipropylxanthine|DPCPX]] have generally low affinity for the A<sub>3</sub> subtype and must be extended by expanding the ring system and adding an aromatic group to give high A<sub>3</sub> affinity and selectivity.<ref name="pmid12570761">{{cite journal | author = Müller CE | title = Medicinal chemistry of adenosine A3 receptor ligands | journal = Current Topics in Medicinal Chemistry | volume = 3 | issue = 4 | pages = 445–62 | year = 2003 | pmid = 12570761 | doi = 10.2174/1568026033392174| url = http://www.bentham-direct.org/pages/content.php?CTMC/2003/00000003/00000004/0008R.SGM | issn = }}</ref> The affinity towards adenosine A<sub>3</sub> subtype was measured against the radioligand PSB-11.<ref name="pmid11814828">{{cite journal | author = Müller CE, Diekmann M, Thorand M, Ozola V | title = [(3)H]8-Ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one ([(3)H]PSB-11), a novel high-affinity antagonist radioligand for human A(3) adenosine receptors. | journal = Bioorg Med Chem Lett | volume = 12 | issue = 3 | pages = 501–3 | year = 2002 | pmid =     11814828 | doi = 10.1016/S0960-894X(01)00785-5  | url = | issn = }}</ref>
+==Chemical Structure and Properties==
-==References==
+PSB-10 is classified as a small [[molecule]] with a specific chemical structure that allows it to interact with biological targets. The molecular formula of PSB-10 is C<sub>18</sub>H<sub>19</sub>ClN<sub>4</sub>O<sub>2</sub>, and it has a molecular weight of approximately 358.82 g/mol. The compound contains a [[chlorine]] atom, which is often involved in the modulation of its biological activity.
-{{reflist}}
-{{Adenosinergics}}
+==Mechanism of Action==
-[[Category:Organochlorides]]
+PSB-10 is known to act as an antagonist at certain [[adenosine receptor]]s, particularly the A<sub>2A</sub> receptor. Adenosine receptors are a class of [[G protein-coupled receptor]]s that play a crucial role in various physiological processes, including [[cardiovascular]] function, [[immune response]], and [[neurotransmission]]. By blocking these receptors, PSB-10 can influence the signaling pathways that are normally activated by the endogenous ligand, adenosine.
-[[Category:Imidazopurines]]
-[[Category:Lactams]]
+==Research Applications==
-{{pharm-stub}}
+In scientific research, PSB-10 is used to study the role of adenosine receptors in different biological systems. It is particularly valuable in [[neuroscience]] research, where it helps to elucidate the function of adenosine in the [[central nervous system]]. Researchers use PSB-10 to investigate its potential effects on [[cognition]], [[memory]], and [[neuroprotection]].
+==Potential Therapeutic Uses==
+While PSB-10 is primarily a research tool, its ability to modulate adenosine receptors suggests potential therapeutic applications. Compounds like PSB-10 could be developed into drugs for treating conditions such as [[Parkinson's disease]], [[chronic pain]], and [[inflammatory disorders]]. However, further research is needed to fully understand its efficacy and safety in clinical settings.
+==Safety and Toxicology==
+As with many research chemicals, the safety profile of PSB-10 is not fully established. It is important for researchers to handle the compound with care and follow appropriate safety protocols. Toxicological studies are necessary to determine its potential effects on human health.
+==Related Pages==
+* [[Adenosine receptor]]
+* [[Pharmacology]]
+* [[Neuroscience]]
+* [[G protein-coupled receptor]]
+[[Category:Chemical compounds]]
+[[Category:Pharmacology]]
+[[Category:Research tools]]