Ciclosporin: Difference between revisions
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{{Short description|Immunosuppressant drug used in organ transplantation and autoimmune diseases}} | |||
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'''Ciclosporin''', also known as '''cyclosporine''', is an [[immunosuppressant]] medication widely used in [[organ transplantation]] to prevent [[rejection (medicine)|rejection]] of the transplanted organ. It is also used in the treatment of various [[autoimmune diseases]]. | |||
==History== | |||
Ciclosporin was discovered in 1971 by researchers at Sandoz (now Novartis) in Switzerland. It was isolated from the fungus ''[[Tolypocladium inflatum]]'' and was found to have potent immunosuppressive properties. The drug was first used in humans in 1978 and received approval for medical use in 1983. | |||
==Mechanism of Action== | |||
Ciclosporin works by inhibiting the activity of [[calcineurin]], a protein phosphatase involved in activating [[T-cells]] of the immune system. By preventing the activation of T-cells, ciclosporin reduces the immune response, which is beneficial in preventing organ rejection and treating autoimmune diseases. | |||
==Medical Uses== | |||
Ciclosporin is primarily used in: | |||
* [[Organ transplantation]]: To prevent rejection of [[kidney]], [[liver]], [[heart]], and other organ transplants. | |||
* [[Autoimmune diseases]]: Such as [[rheumatoid arthritis]], [[psoriasis]], and [[Crohn's disease]]. | |||
* [[Ophthalmology]]: As an eye drop formulation to treat [[dry eye syndrome]]. | |||
==Side Effects== | |||
Common side effects of ciclosporin include: | |||
* [[Hypertension]] | |||
* [[Nephrotoxicity]] | |||
* [[Hirsutism]] | |||
* [[Gingival hyperplasia]] | |||
* [[Hyperlipidemia]] | |||
Long-term use of ciclosporin can lead to increased risk of [[infections]] and [[malignancies]] due to its immunosuppressive effects. | |||
==Pharmacokinetics== | |||
Ciclosporin is metabolized in the [[liver]] by the [[cytochrome P450]] enzyme system, particularly CYP3A4. It is excreted primarily in the [[bile]] and has a variable half-life depending on the individual. | |||
==Formulations== | |||
Ciclosporin is available in several formulations, including: | |||
* Oral capsules | |||
* Oral solution | |||
* Intravenous injection | |||
* Ophthalmic emulsion (eye drops) | |||
==Related Pages== | |||
* [[Immunosuppressive drug]] | |||
* [[Organ transplantation]] | |||
* [[Autoimmune disease]] | |||
[[Category:Immunosuppressants]] | |||
[[Category:Organ transplantation]] | |||
[[Category:Autoimmune diseases]] | |||
Latest revision as of 21:25, 4 March 2025
Immunosuppressant drug used in organ transplantation and autoimmune diseases
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Ciclosporin, also known as cyclosporine, is an immunosuppressant medication widely used in organ transplantation to prevent rejection of the transplanted organ. It is also used in the treatment of various autoimmune diseases.
History[edit]
Ciclosporin was discovered in 1971 by researchers at Sandoz (now Novartis) in Switzerland. It was isolated from the fungus Tolypocladium inflatum and was found to have potent immunosuppressive properties. The drug was first used in humans in 1978 and received approval for medical use in 1983.
Mechanism of Action[edit]
Ciclosporin works by inhibiting the activity of calcineurin, a protein phosphatase involved in activating T-cells of the immune system. By preventing the activation of T-cells, ciclosporin reduces the immune response, which is beneficial in preventing organ rejection and treating autoimmune diseases.
Medical Uses[edit]
Ciclosporin is primarily used in:
- Organ transplantation: To prevent rejection of kidney, liver, heart, and other organ transplants.
- Autoimmune diseases: Such as rheumatoid arthritis, psoriasis, and Crohn's disease.
- Ophthalmology: As an eye drop formulation to treat dry eye syndrome.
Side Effects[edit]
Common side effects of ciclosporin include:
Long-term use of ciclosporin can lead to increased risk of infections and malignancies due to its immunosuppressive effects.
Pharmacokinetics[edit]
Ciclosporin is metabolized in the liver by the cytochrome P450 enzyme system, particularly CYP3A4. It is excreted primarily in the bile and has a variable half-life depending on the individual.
Formulations[edit]
Ciclosporin is available in several formulations, including:
- Oral capsules
- Oral solution
- Intravenous injection
- Ophthalmic emulsion (eye drops)
