Prednisolone sodium phosphate

An article about the medication Prednisolone sodium phosphate

Prednisolone sodium phosphate
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

Prednisolone sodium phosphate is a glucocorticoid medication used to treat a variety of inflammatory and autoimmune conditions. It is a water-soluble ester of prednisolone, which is a synthetic analog of the naturally occurring hormone cortisol.

Medical Uses

Prednisolone sodium phosphate is commonly prescribed for conditions such as:

• Asthma
• Rheumatoid arthritis
• Allergic reactions
• Inflammatory bowel disease
• Multiple sclerosis

The medication works by suppressing the immune system and reducing inflammation. It is often used when oral administration is preferred, as it is available in liquid form, making it suitable for patients who have difficulty swallowing tablets.

Mechanism of Action

Prednisolone sodium phosphate exerts its effects by binding to glucocorticoid receptors, which then translocate to the cell nucleus and modulate the expression of specific genes. This results in the suppression of pro-inflammatory cytokines and the promotion of anti-inflammatory proteins.

Side Effects

Common side effects of prednisolone sodium phosphate include:

• Increased appetite
• Weight gain
• Insomnia
• Mood changes
• Increased risk of infections

Long-term use can lead to more serious side effects such as osteoporosis, hypertension, and diabetes mellitus.

Dosage and Administration

The dosage of prednisolone sodium phosphate varies depending on the condition being treated and the patient's response to therapy. It is important to follow the prescribing physician's instructions and not to discontinue the medication abruptly, as this can lead to adrenal insufficiency.

Interactions

Prednisolone sodium phosphate can interact with a variety of medications, including:

• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Anticoagulants
• Diuretics

Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.

Also see

• Glucocorticoid
• Corticosteroid
• Prednisone
• Hydrocortisone

References

• 
  Prednisolone sodium phosphate