Cyclothiazide

Cyclothiazide is a diuretic and antihypertensive drug that belongs to the class of thiazide diuretics. It is primarily used in the treatment of hypertension and edema.

Mechanism of Action

Cyclothiazide works by inhibiting the sodium-chloride symporter in the distal convoluted tubule of the nephron. This results in an increase in the excretion of sodium, chloride, and water from the body, thereby reducing blood pressure and decreasing edema.

Side Effects

Common side effects of cyclothiazide include dizziness, headache, nausea, and vomiting. In rare cases, it can cause severe hypokalemia, hyponatremia, and hypercalcemia.

Contraindications

Cyclothiazide is contraindicated in patients with known hypersensitivity to thiazide diuretics or sulfonamide derivatives. It should also be used with caution in patients with severe renal impairment or hepatic impairment.

Interactions

Cyclothiazide can interact with several other medications, including digoxin, lithium, and nonsteroidal anti-inflammatory drugs (NSAIDs). It can also interact with alcohol, increasing the risk of orthostatic hypotension.

Dosage

The dosage of cyclothiazide varies depending on the condition being treated and the patient's response to therapy. It is usually taken once daily, either in the morning or evening.

See Also

• Thiazide diuretics
• Hypertension
• Edema

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