Paramethasone acetate: Difference between revisions
CSV import Tags: mobile edit mobile web edit |
CSV import |
||
| Line 1: | Line 1: | ||
'''Paramethasone | {{Short description|A synthetic glucocorticoid corticosteroid}} | ||
{{Drugbox | |||
| verifiedfields = changed | |||
| verifiedrevid = 477002123 | |||
| image = Paramethasone_acetate.svg | |||
| image_size = 200px | |||
| image_alt = Structural formula of Paramethasone acetate | |||
| image_caption = Structural formula of Paramethasone acetate | |||
}} | |||
'''Paramethasone acetate''' is a [[synthetic]] [[glucocorticoid]] [[corticosteroid]] used in the treatment of various inflammatory and autoimmune conditions. It is a derivative of [[paramethasone]], modified to enhance its [[pharmacokinetics]] and [[pharmacodynamics]]. | |||
==Pharmacology== | ==Pharmacology== | ||
Paramethasone | Paramethasone acetate functions by mimicking the effects of [[cortisol]], a natural hormone produced by the [[adrenal cortex]]. It exerts its effects by binding to the [[glucocorticoid receptor]], leading to changes in [[gene expression]] that result in anti-inflammatory and immunosuppressive effects. | ||
===Mechanism of Action=== | |||
The primary mechanism of action of paramethasone acetate involves the suppression of [[inflammatory mediators]] such as [[cytokines]], [[prostaglandins]], and [[leukotrienes]]. By inhibiting the [[arachidonic acid]] pathway, it reduces the production of these mediators, thereby decreasing inflammation and immune response. | |||
===Pharmacokinetics=== | |||
Paramethasone acetate is well absorbed when administered orally. It undergoes hepatic metabolism and is excreted primarily via the kidneys. The acetate ester increases its [[lipophilicity]], enhancing its absorption and duration of action compared to its parent compound, paramethasone. | |||
==Uses== | ==Clinical Uses== | ||
Paramethasone | Paramethasone acetate is indicated for the management of conditions such as [[rheumatoid arthritis]], [[systemic lupus erythematosus]], [[asthma]], and [[allergic reactions]]. It is also used in the treatment of [[adrenal insufficiency]] and certain types of [[cancer]] as part of [[chemotherapy]] regimens. | ||
==Side Effects== | ==Side Effects== | ||
Common side effects of paramethasone acetate include [[hypertension]], [[hyperglycemia]], [[osteoporosis]], and increased susceptibility to [[infections]]. Long-term use can lead to [[Cushing's syndrome]], characterized by [[weight gain]], [[moon face]], and [[buffalo hump]]. | |||
== | ==Contraindications== | ||
Paramethasone acetate is contraindicated in patients with systemic [[fungal infections]] and those with known hypersensitivity to the drug. Caution is advised in patients with [[diabetes mellitus]], [[peptic ulcer disease]], and [[hypertension]]. | |||
== | ==Related pages== | ||
* [[Glucocorticoid]] | * [[Glucocorticoid]] | ||
* [[ | * [[Corticosteroid]] | ||
* [[ | * [[Inflammation]] | ||
* [[ | * [[Autoimmune disease]] | ||
[[Category:Glucocorticoids]] | [[Category:Glucocorticoids]] | ||
[[Category: | [[Category:Corticosteroids]] | ||
Latest revision as of 05:37, 16 February 2025
A synthetic glucocorticoid corticosteroid
| Paramethasone acetate | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
Paramethasone acetate is a synthetic glucocorticoid corticosteroid used in the treatment of various inflammatory and autoimmune conditions. It is a derivative of paramethasone, modified to enhance its pharmacokinetics and pharmacodynamics.
Pharmacology[edit]
Paramethasone acetate functions by mimicking the effects of cortisol, a natural hormone produced by the adrenal cortex. It exerts its effects by binding to the glucocorticoid receptor, leading to changes in gene expression that result in anti-inflammatory and immunosuppressive effects.
Mechanism of Action[edit]
The primary mechanism of action of paramethasone acetate involves the suppression of inflammatory mediators such as cytokines, prostaglandins, and leukotrienes. By inhibiting the arachidonic acid pathway, it reduces the production of these mediators, thereby decreasing inflammation and immune response.
Pharmacokinetics[edit]
Paramethasone acetate is well absorbed when administered orally. It undergoes hepatic metabolism and is excreted primarily via the kidneys. The acetate ester increases its lipophilicity, enhancing its absorption and duration of action compared to its parent compound, paramethasone.
Clinical Uses[edit]
Paramethasone acetate is indicated for the management of conditions such as rheumatoid arthritis, systemic lupus erythematosus, asthma, and allergic reactions. It is also used in the treatment of adrenal insufficiency and certain types of cancer as part of chemotherapy regimens.
Side Effects[edit]
Common side effects of paramethasone acetate include hypertension, hyperglycemia, osteoporosis, and increased susceptibility to infections. Long-term use can lead to Cushing's syndrome, characterized by weight gain, moon face, and buffalo hump.
Contraindications[edit]
Paramethasone acetate is contraindicated in patients with systemic fungal infections and those with known hypersensitivity to the drug. Caution is advised in patients with diabetes mellitus, peptic ulcer disease, and hypertension.
