Nepafenac: Difference between revisions
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{{Short description|A non-steroidal anti-inflammatory drug used in ophthalmology}} | |||
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'''Nepafenac''' is a [[non-steroidal anti-inflammatory drug]] (NSAID) used in [[ophthalmology]] to manage pain and inflammation associated with [[cataract surgery]]. It is a [[prodrug]] that is converted to its active form, [[amfenac]], in the eye. | |||
Nepafenac is a prodrug that | |||
== | ==Mechanism of Action== | ||
Nepafenac | Nepafenac works by inhibiting the [[cyclooxygenase]] (COX) enzymes, which are responsible for the synthesis of [[prostaglandins]]. Prostaglandins are mediators of inflammation and pain. By reducing their production, nepafenac helps to alleviate these symptoms. | ||
== | ==Pharmacokinetics== | ||
Nepafenac is administered as an [[ophthalmic suspension]]. Upon instillation into the eye, it penetrates the corneal tissue and is rapidly converted by intraocular hydrolases to amfenac, which is the active form. Amfenac then inhibits the COX enzymes within the eye. | |||
== | ==Clinical Uses== | ||
Nepafenac | Nepafenac is primarily used to reduce pain and inflammation following [[cataract surgery]]. It may also be used in other ocular inflammatory conditions as deemed appropriate by a healthcare provider. | ||
== | ==Side Effects== | ||
* [[ | Common side effects of nepafenac include: | ||
* Transient burning or stinging upon application | |||
* [[Conjunctival hyperemia]] | |||
* [[Corneal edema]] | |||
Serious side effects are rare but may include: | |||
* [[Corneal thinning]] | |||
* [[Corneal erosion]] | |||
* [[Delayed wound healing]] | |||
==Contraindications== | |||
Nepafenac should not be used in patients with known hypersensitivity to nepafenac, amfenac, or any other components of the formulation. Caution is advised in patients with a history of [[bleeding disorders]] or those taking other medications that may increase bleeding risk. | |||
==Related pages== | |||
* [[Non-steroidal anti-inflammatory drug]] | |||
* [[Cataract surgery]] | * [[Cataract surgery]] | ||
* [[ | * [[Prostaglandin]] | ||
[[Category: | [[Category:Non-steroidal anti-inflammatory drugs]] | ||
[[Category:Ophthalmology]] | [[Category:Ophthalmology]] | ||
Revision as of 11:50, 15 February 2025
A non-steroidal anti-inflammatory drug used in ophthalmology
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Nepafenac is a non-steroidal anti-inflammatory drug (NSAID) used in ophthalmology to manage pain and inflammation associated with cataract surgery. It is a prodrug that is converted to its active form, amfenac, in the eye.
Mechanism of Action
Nepafenac works by inhibiting the cyclooxygenase (COX) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of inflammation and pain. By reducing their production, nepafenac helps to alleviate these symptoms.
Pharmacokinetics
Nepafenac is administered as an ophthalmic suspension. Upon instillation into the eye, it penetrates the corneal tissue and is rapidly converted by intraocular hydrolases to amfenac, which is the active form. Amfenac then inhibits the COX enzymes within the eye.
Clinical Uses
Nepafenac is primarily used to reduce pain and inflammation following cataract surgery. It may also be used in other ocular inflammatory conditions as deemed appropriate by a healthcare provider.
Side Effects
Common side effects of nepafenac include:
- Transient burning or stinging upon application
- Conjunctival hyperemia
- Corneal edema
Serious side effects are rare but may include:
Contraindications
Nepafenac should not be used in patients with known hypersensitivity to nepafenac, amfenac, or any other components of the formulation. Caution is advised in patients with a history of bleeding disorders or those taking other medications that may increase bleeding risk.
