Tannerella forsythia: Difference between revisions
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{{Short description|A bacterium associated with periodontal disease}} | |||
{{Taxobox | |||
| name = Tannerella forsythia | |||
| image = Wikidata_link.PNG | |||
| image_caption = Tannerella forsythia | |||
| domain = [[Bacteria]] | |||
| phylum = [[Bacteroidota]] | |||
| classis = [[Bacteroidia]] | |||
| ordo = [[Bacteroidales]] | |||
| familia = [[Tannerellaceae]] | |||
| genus = ''[[Tannerella]]'' | |||
| species = '''''T. forsythia''''' | |||
| binomial = ''Tannerella forsythia'' | |||
}} | |||
'''''Tannerella forsythia''''' is a [[Gram-negative]] anaerobic bacterium that is implicated in [[periodontal disease]]. It is part of the [[red complex]], a group of bacteria that are strongly associated with [[chronic periodontitis]]. | |||
==Morphology== | |||
''Tannerella forsythia'' is a [[rod-shaped]] bacterium. It is non-motile and does not form spores. The cells are typically 0.5 to 0.7 micrometers in width and 2.5 to 3.5 micrometers in length. The bacterium has a characteristic [[S-layer]] on its surface, which is thought to play a role in its virulence. | |||
== | ==Pathogenicity== | ||
''Tannerella forsythia'' is considered a key pathogen in the development of [[periodontitis]], a serious gum infection that damages the soft tissue and destroys the bone that supports the teeth. It is often found in association with other periodontal pathogens such as ''[[Porphyromonas gingivalis]]'' and ''[[Treponema denticola]]''. | |||
===Virulence Factors=== | |||
The virulence of ''Tannerella forsythia'' is attributed to several factors: | |||
* '''S-layer''': The surface layer (S-layer) of ''T. forsythia'' is involved in adhesion and immune evasion. | |||
* '''Proteolytic enzymes''': The bacterium produces enzymes that degrade host proteins, aiding in tissue destruction and immune evasion. | |||
* '''Biofilm formation''': ''T. forsythia'' can form biofilms, which protect the bacteria from the host immune response and increase resistance to antibiotics. | |||
== | ==Clinical Significance== | ||
''Tannerella forsythia'' is a significant contributor to [[periodontal disease]], which can lead to tooth loss if untreated. It is also associated with [[systemic diseases]] such as [[cardiovascular disease]] and [[diabetes mellitus]], due to the inflammatory response it triggers. | |||
==Diagnosis and Treatment== | |||
Diagnosis of infections involving ''Tannerella forsythia'' typically involves clinical examination and microbiological testing, including [[polymerase chain reaction]] (PCR) assays to detect bacterial DNA. Treatment involves mechanical debridement of the periodontal pockets and the use of [[antibiotics]] such as [[metronidazole]] and [[amoxicillin]]. | |||
== | ==Related pages== | ||
* [[Periodontal disease]] | |||
* [[Porphyromonas gingivalis]] | |||
* [[Treponema denticola]] | |||
* [[Biofilm]] | |||
[[Category:Tannerellaceae]] | |||
[[Category:Periodontal pathogens]] | |||
[[Category: | |||
[[Category: | |||
Revision as of 11:14, 15 February 2025
A bacterium associated with periodontal disease
Tannerella forsythia is a Gram-negative anaerobic bacterium that is implicated in periodontal disease. It is part of the red complex, a group of bacteria that are strongly associated with chronic periodontitis.
Morphology
Tannerella forsythia is a rod-shaped bacterium. It is non-motile and does not form spores. The cells are typically 0.5 to 0.7 micrometers in width and 2.5 to 3.5 micrometers in length. The bacterium has a characteristic S-layer on its surface, which is thought to play a role in its virulence.
Pathogenicity
Tannerella forsythia is considered a key pathogen in the development of periodontitis, a serious gum infection that damages the soft tissue and destroys the bone that supports the teeth. It is often found in association with other periodontal pathogens such as Porphyromonas gingivalis and Treponema denticola.
Virulence Factors
The virulence of Tannerella forsythia is attributed to several factors:
- S-layer: The surface layer (S-layer) of T. forsythia is involved in adhesion and immune evasion.
- Proteolytic enzymes: The bacterium produces enzymes that degrade host proteins, aiding in tissue destruction and immune evasion.
- Biofilm formation: T. forsythia can form biofilms, which protect the bacteria from the host immune response and increase resistance to antibiotics.
Clinical Significance
Tannerella forsythia is a significant contributor to periodontal disease, which can lead to tooth loss if untreated. It is also associated with systemic diseases such as cardiovascular disease and diabetes mellitus, due to the inflammatory response it triggers.
Diagnosis and Treatment
Diagnosis of infections involving Tannerella forsythia typically involves clinical examination and microbiological testing, including polymerase chain reaction (PCR) assays to detect bacterial DNA. Treatment involves mechanical debridement of the periodontal pockets and the use of antibiotics such as metronidazole and amoxicillin.
