Telenzepine: Difference between revisions

Telenzepine
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Revision as of 04:05, 13 February 2025

Overview of the antimuscarinic drug Telenzepine

Telenzepine is a pharmacological agent classified as an antimuscarinic drug. It is primarily used in the treatment of gastrointestinal disorders due to its ability to selectively inhibit muscarinic receptors in the gastrointestinal tract.

Mechanism of Action

Telenzepine functions by selectively blocking the M1 subtype of muscarinic receptors. These receptors are predominantly located in the central nervous system and the gastrointestinal tract. By inhibiting these receptors, telenzepine reduces gastric acid secretion, making it effective in the management of peptic ulcer disease.

Pharmacokinetics

Telenzepine is administered orally and is absorbed through the gastrointestinal tract. It undergoes hepatic metabolism and is excreted primarily via the renal system. The drug has a moderate half-life, allowing for convenient dosing schedules in clinical practice.

Clinical Uses

Telenzepine is used in the treatment of conditions such as:

Its selective action on M1 receptors makes it a preferred choice in patients where reduction of gastric acid secretion is desired without significant systemic side effects.

Side Effects

Common side effects of telenzepine include:

These side effects are typical of antimuscarinic agents due to their action on muscarinic receptors in various parts of the body.

Related pages

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-'''Telenzepine''' is a [[muscarinic antagonist]] that is used in the treatment of [[peptic ulcer disease]]. It is a selective [[M1 receptor antagonist]] that is primarily used in the treatment of [[gastrointestinal disorders]]. Telenzepine is not available in the United States, but is available in other countries, including Japan and the United Kingdom.
+{{Short description|Overview of the antimuscarinic drug Telenzepine}}
+{{Drugbox
+| verifiedfields = changed
+| verifiedrevid = 477002123
+| image = Telenzepine.svg
+| image_size = 200px
+| image_alt = Chemical structure of Telenzepine
+}}
-==Pharmacology==
+'''Telenzepine''' is a [[pharmacology|pharmacological]] agent classified as an [[antimuscarinic]] drug. It is primarily used in the treatment of [[gastrointestinal]] disorders due to its ability to selectively inhibit [[muscarinic acetylcholine receptor|muscarinic receptors]] in the [[gastrointestinal tract]].
-Telenzepine is a [[muscarinic antagonist]], which means it works by blocking the action of [[acetylcholine]], a neurotransmitter that is involved in the contraction of smooth muscles and the secretion of gastric acid. By blocking the action of acetylcholine, telenzepine reduces the production of gastric acid, which can help to heal peptic ulcers and reduce symptoms of gastrointestinal disorders.
-Telenzepine is a selective antagonist of the M1 subtype of muscarinic receptors. This means it has a greater affinity for M1 receptors than for other subtypes of muscarinic receptors. This selectivity makes telenzepine more effective in reducing gastric acid secretion than non-selective muscarinic antagonists.
+==Mechanism of Action==
+Telenzepine functions by selectively blocking the [[M1 receptor|M1 subtype]] of muscarinic receptors. These receptors are predominantly located in the [[central nervous system]] and the [[gastrointestinal tract]]. By inhibiting these receptors, telenzepine reduces [[gastric acid secretion]], making it effective in the management of [[peptic ulcer disease]].
-==Clinical use==
+==Pharmacokinetics==
-Telenzepine is used in the treatment of peptic ulcer disease and other gastrointestinal disorders. It is not available in the United States, but is available in other countries, including Japan and the United Kingdom.
+Telenzepine is administered orally and is absorbed through the [[gastrointestinal tract]]. It undergoes [[hepatic metabolism]] and is excreted primarily via the [[renal system]]. The drug has a moderate half-life, allowing for convenient dosing schedules in clinical practice.
-==Side effects==
+==Clinical Uses==
-The most common side effects of telenzepine are dry mouth, blurred vision, constipation, and urinary retention. These side effects are due to the blockade of muscarinic receptors in the salivary glands, eyes, gastrointestinal tract, and urinary tract.
+Telenzepine is used in the treatment of conditions such as:
+* [[Peptic ulcer disease]]
+* [[Gastroesophageal reflux disease]] (GERD)
+* [[Functional dyspepsia]]
-==See also==
+Its selective action on M1 receptors makes it a preferred choice in patients where reduction of gastric acid secretion is desired without significant [[systemic side effects]].
-* [[Muscarinic antagonist]]
+==Side Effects==
+Common side effects of telenzepine include:
+* [[Dry mouth]]
+* [[Constipation]]
+* [[Blurred vision]]
+These side effects are typical of antimuscarinic agents due to their action on [[muscarinic receptors]] in various parts of the body.
+==Related pages==
+* [[Antimuscarinic]]
+* [[Muscarinic acetylcholine receptor]]
 * [[Peptic ulcer disease]]
-* [[Gastrointestinal disorders]]
-[[Category:Drugs]]
-[[Category:Muscarinic antagonists]]
-[[Category:Peptic ulcer disease]]
-[[Category:Gastrointestinal disorders]]
-{{stub}}
+[[Category:Antimuscarinic drugs]]
+[[Category:Gastrointestinal agents]]