SIN3A: Difference between revisions

Latest revision as of 20:39, 30 December 2024

SIN3A is a protein that in humans is encoded by the SIN3A gene. This protein is a component of the histone deacetylase complex, which is involved in the regulation of gene expression by modifying chromatin structure.

Function[edit]

SIN3A is a core component of the histone deacetylase complex, which plays a critical role in the regulation of transcription by altering the acetylation status of histones. This modification affects the accessibility of DNA to transcription factors and other proteins, thereby influencing gene expression.

Interactions[edit]

SIN3A interacts with a variety of proteins, including:

HDAC1 and HDAC2 - Histone deacetylases that are part of the same complex.
SAP30 - A protein that helps recruit SIN3A to specific genomic locations.
MECP2 - A protein involved in gene silencing and associated with Rett syndrome.

Clinical significance[edit]

Mutations or dysregulation of SIN3A have been implicated in various cancers and neurological disorders. Its role in epigenetic regulation makes it a potential target for therapeutic interventions.

References[edit]

External links[edit]

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-'''SIN3A''' is a protein that in humans is encoded by the SIN3A gene. It is a transcriptional regulatory protein, involved in chromatin remodeling and gene expression.
-== Function ==
+{{Infobox protein
+| name = SIN3A
+| image = <!-- Image removed -->
+| caption = <!-- Caption removed -->
+| symbol = SIN3A
+| alt_symbols = KIAA0700
+| EntrezGene = 25942
+| HGNCid = 10765
+| OMIM = 607776
+| RefSeq = NM_001145357
+| UniProt = Q96ST3
+}}
-[[SIN3A]] is a master regulator of gene expression and is involved in many biological processes, including cell cycle regulation, differentiation, and apoptosis. It functions as a scaffold protein, interacting with a variety of transcription factors and other regulatory proteins to repress gene expression.
+'''SIN3A''' is a [[protein]] that in humans is encoded by the '''SIN3A''' [[gene]]. This protein is a component of the [[histone deacetylase]] complex, which is involved in the regulation of [[gene expression]] by modifying [[chromatin]] structure.
-[[SIN3A]] is part of the [[SIN3]]-histone deacetylase (HDAC) complex, which removes acetyl groups from histones, leading to a more compact and less transcriptionally active chromatin structure. This is a key mechanism of gene repression.
+== Function ==
+SIN3A is a core component of the [[histone deacetylase complex]], which plays a critical role in the regulation of [[transcription]] by altering the [[acetylation]] status of [[histones]]. This modification affects the accessibility of [[DNA]] to [[transcription factors]] and other proteins, thereby influencing [[gene expression]].
-== Structure ==
+== Interactions ==
+SIN3A interacts with a variety of proteins, including:
-The [[SIN3A]] protein is composed of several domains, including four paired amphipathic helix (PAH) domains, which are involved in protein-protein interactions. It also contains a highly conserved region known as the HID (HDAC interaction domain), which is responsible for binding to HDACs.
+* [[HDAC1]] and [[HDAC2]] - Histone deacetylases that are part of the same complex.
+* [[SAP30]] - A protein that helps recruit SIN3A to specific genomic locations.
+* [[MECP2]] - A protein involved in [[gene silencing]] and associated with [[Rett syndrome]].
 == Clinical significance ==
+Mutations or dysregulation of SIN3A have been implicated in various [[cancers]] and [[neurological disorders]]. Its role in [[epigenetic regulation]] makes it a potential target for therapeutic interventions.
-Mutations in the [[SIN3A]] gene have been associated with several types of cancer, including breast cancer and lung cancer. These mutations often result in a loss of function of the SIN3A protein, leading to dysregulated gene expression and uncontrolled cell growth.
-In addition, [[SIN3A]] has been implicated in neurological disorders such as autism and intellectual disability. Studies have shown that mutations in the SIN3A gene can disrupt normal brain development and function.
-== Research ==
-Research on [[SIN3A]] is ongoing, with scientists seeking to better understand its role in gene regulation and disease. This research could potentially lead to new therapeutic strategies for treating diseases associated with SIN3A dysfunction.
-[[File:SIN3A protein structure.jpg|thumb|right|Structure of the SIN3A protein.]]
 == See also ==
-* [[SIN3B]]
 * [[Histone deacetylase]]
-* [[Transcription (genetics)]]
+* [[Chromatin remodeling]]
+* [[Gene regulation]]
 == References ==
+<references />
-{{Reflist}}
+== External links ==
+* {{GeneReviews|SIN3A}}
+* {{OMIM|607776}}
 [[Category:Human proteins]]
-[[Category:Transcription factors]]
 [[Category:Gene expression]]
-[[Category:Genetics]]
+[[Category:Epigenetics]]
-[[Category:Medicine]]
-{{protein-stub}}
-{{medicine-stub}}