TRPC5: Difference between revisions

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'''TRPC5''' is a protein that in humans is encoded by the '''TRPC5''' gene. It is a member of the transient receptor potential channel (TRPC) group of ion channels. These channels are involved in various types of sensory perception and are known to influence a wide range of biological and physiological processes.
 
{{Infobox protein
| name = TRPC5
| image = <!-- Image removed -->
| caption = <!-- Image caption removed -->
| symbol = TRPC5
| alt_symbols = TRP5
| EntrezGene = 7224
| HGNCid = 12338
| OMIM = 606565
| RefSeq = NM_012471
| UniProt = Q9UL62
| chromosome = 11
| arm = q
| band = 21
}}
 
'''TRPC5''' (Transient Receptor Potential Cation Channel Subfamily C Member 5) is a protein that in humans is encoded by the [[TRPC5 gene]]. It is a member of the [[transient receptor potential channel]] (TRP) family, which are [[ion channels]] involved in various physiological processes.


== Function ==
== Function ==
[[TRPC5]] is a non-selective cation channel that is activated in response to changes in the cellular environment. It is permeable to calcium ions, which play a crucial role in cellular signaling pathways. The channel is thought to be involved in the regulation of neuronal growth and development, as well as in the modulation of neuronal excitability.
TRPC5 is a [[calcium]]-permeable, non-selective cation channel that is activated by [[receptor-operated]] and [[store-operated]] mechanisms. It plays a role in the regulation of [[calcium signaling]] in various cell types. TRPC5 is involved in the modulation of [[neuronal growth cone]] dynamics, which is crucial for [[neuronal development]] and [[synaptic plasticity]].
 
== Structure ==
The [[TRPC5]] protein is composed of six transmembrane domains, with a pore region located between the fifth and sixth domains. The N- and C-termini of the protein are located in the cytoplasm. The N-terminus contains ankyrin repeats, which are thought to be involved in protein-protein interactions.


== Clinical significance ==
== Expression ==
Mutations in the [[TRPC5]] gene have been associated with a number of neurological disorders, including [[autism]], [[schizophrenia]], and [[bipolar disorder]]. In addition, overexpression of TRPC5 has been observed in certain types of cancer, suggesting a potential role in tumorigenesis.
TRPC5 is widely expressed in the [[central nervous system]], including the [[hippocampus]], [[cerebellum]], and [[cortex]]. It is also found in other tissues such as the [[kidney]], [[lung]], and [[heart]].


== Research ==
== Clinical Significance ==
Research into the function and regulation of [[TRPC5]] is ongoing, with a particular focus on its role in neurological disorders and cancer. Understanding the mechanisms by which TRPC5 contributes to these conditions could potentially lead to the development of new therapeutic strategies.
Alterations in TRPC5 function have been implicated in various [[neurological disorders]], including [[anxiety]], [[depression]], and [[schizophrenia]]. TRPC5 is also being studied for its role in [[renal disease]] and [[cardiovascular disease]].


[[File:TRPC5.png|thumb|right|300px|Structure of the TRPC5 protein.]]
== Interactions ==
TRPC5 interacts with several proteins, including [[calmodulin]], [[inositol trisphosphate receptor]] (IP3R), and [[phospholipase C]]. These interactions are important for its regulation and function in cellular signaling pathways.


== See also ==
== See also ==
* [[Transient receptor potential channel]]
* [[TRPC channel]]
* [[Calcium signaling]]
* [[Calcium signaling]]
* [[Neurological disorders]]
* [[Ion channel]]
* [[Cancer]]


== References ==
== References ==
<references />
<references />
== External links ==
* [https://www.ncbi.nlm.nih.gov/gene/7224 TRPC5 Gene - NCBI]
* [https://www.uniprot.org/uniprot/Q9UL62 TRPC5 Protein - UniProt]
{{Ion channels}}
{{TRP channels}}


[[Category:Ion channels]]
[[Category:Ion channels]]
[[Category:Proteins]]
[[Category:TRP channels]]
[[Category:Neurology]]
[[Category:Human proteins]]
[[Category:Oncology]]
[[Category:Genes on chromosome 11]]
 
{{medicine-stub}}

Latest revision as of 20:32, 30 December 2024


TRPC5 (Transient Receptor Potential Cation Channel Subfamily C Member 5) is a protein that in humans is encoded by the TRPC5 gene. It is a member of the transient receptor potential channel (TRP) family, which are ion channels involved in various physiological processes.

Function[edit]

TRPC5 is a calcium-permeable, non-selective cation channel that is activated by receptor-operated and store-operated mechanisms. It plays a role in the regulation of calcium signaling in various cell types. TRPC5 is involved in the modulation of neuronal growth cone dynamics, which is crucial for neuronal development and synaptic plasticity.

Expression[edit]

TRPC5 is widely expressed in the central nervous system, including the hippocampus, cerebellum, and cortex. It is also found in other tissues such as the kidney, lung, and heart.

Clinical Significance[edit]

Alterations in TRPC5 function have been implicated in various neurological disorders, including anxiety, depression, and schizophrenia. TRPC5 is also being studied for its role in renal disease and cardiovascular disease.

Interactions[edit]

TRPC5 interacts with several proteins, including calmodulin, inositol trisphosphate receptor (IP3R), and phospholipase C. These interactions are important for its regulation and function in cellular signaling pathways.

See also[edit]

References[edit]

<references />

External links[edit]








see also disorders


Template:TRP channels

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