Nilvadipine: Difference between revisions
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{{Short description| | {{Short description|Calcium channel blocker used in the treatment of hypertension}} | ||
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| image = Nilvadipine_structure.svg | | image = Nilvadipine_structure.svg | ||
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'''Nilvadipine''' is a [[calcium channel blocker]] of | '''Nilvadipine''' is a [[calcium channel blocker]] used primarily in the treatment of [[hypertension]] (high blood pressure). It belongs to the class of medications known as [[dihydropyridine]] calcium channel blockers, which are known for their ability to relax and widen blood vessels, thereby improving blood flow and reducing blood pressure. | ||
==Pharmacology== | ==Pharmacology== | ||
Nilvadipine works by inhibiting the influx of calcium ions through [[L-type calcium channel|L-type calcium channels]] in the [[smooth muscle]] cells of the [[vascular system]]. This action leads to the relaxation of vascular smooth muscle, resulting in [[vasodilation]] and a subsequent decrease in [[blood pressure]]. | Nilvadipine works by inhibiting the influx of calcium ions through [[L-type calcium channel|L-type calcium channels]] in the [[smooth muscle]] cells of the [[vascular system]]. This action leads to the relaxation of vascular smooth muscle, resulting in [[vasodilation]] and a subsequent decrease in blood pressure. The drug is particularly effective in reducing [[systolic blood pressure]], which is the pressure in the arteries when the heart beats. | ||
== | ==Clinical Use== | ||
Nilvadipine is primarily prescribed for the management of hypertension. It may be used alone or in combination with other antihypertensive agents. The drug is administered orally, and the dosage is typically adjusted based on the patient's response and tolerance. | |||
== | ==Side Effects== | ||
Common side effects of nilvadipine include [[headache]], [[dizziness]], [[flushing]], and [[edema]] (swelling), particularly in the lower extremities. These side effects are generally mild and tend to diminish with continued use. In rare cases, more severe side effects such as [[hypotension]] (abnormally low blood pressure) and [[tachycardia]] (rapid heart rate) may occur. | |||
== | ==Contraindications== | ||
Nilvadipine is contraindicated in patients with known hypersensitivity to the drug or any of its components. Caution is advised when prescribing nilvadipine to patients with severe [[aortic stenosis]], as the drug's vasodilatory effects may exacerbate the condition. | |||
== | ==Research== | ||
Research has been conducted to explore the potential neuroprotective effects of nilvadipine, particularly in the context of [[Alzheimer's disease]]. Some studies suggest that nilvadipine may help reduce [[cerebral blood flow]] abnormalities and [[amyloid beta]] accumulation, which are characteristic of Alzheimer's disease. However, more research is needed to fully understand its efficacy and safety in this context. | |||
==Related pages== | ==Related pages== | ||
* [[Calcium channel blocker]] | * [[Calcium channel blocker]] | ||
* [[Hypertension]] | * [[Hypertension]] | ||
* [[ | * [[Dihydropyridine]] | ||
[[Category:Calcium channel blockers]] | [[Category:Calcium channel blockers]] | ||
[[Category:Antihypertensive agents]] | [[Category:Antihypertensive agents]] | ||
Latest revision as of 11:30, 23 March 2025
Calcium channel blocker used in the treatment of hypertension
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Nilvadipine is a calcium channel blocker used primarily in the treatment of hypertension (high blood pressure). It belongs to the class of medications known as dihydropyridine calcium channel blockers, which are known for their ability to relax and widen blood vessels, thereby improving blood flow and reducing blood pressure.
Pharmacology[edit]
Nilvadipine works by inhibiting the influx of calcium ions through L-type calcium channels in the smooth muscle cells of the vascular system. This action leads to the relaxation of vascular smooth muscle, resulting in vasodilation and a subsequent decrease in blood pressure. The drug is particularly effective in reducing systolic blood pressure, which is the pressure in the arteries when the heart beats.
Clinical Use[edit]
Nilvadipine is primarily prescribed for the management of hypertension. It may be used alone or in combination with other antihypertensive agents. The drug is administered orally, and the dosage is typically adjusted based on the patient's response and tolerance.
Side Effects[edit]
Common side effects of nilvadipine include headache, dizziness, flushing, and edema (swelling), particularly in the lower extremities. These side effects are generally mild and tend to diminish with continued use. In rare cases, more severe side effects such as hypotension (abnormally low blood pressure) and tachycardia (rapid heart rate) may occur.
Contraindications[edit]
Nilvadipine is contraindicated in patients with known hypersensitivity to the drug or any of its components. Caution is advised when prescribing nilvadipine to patients with severe aortic stenosis, as the drug's vasodilatory effects may exacerbate the condition.
Research[edit]
Research has been conducted to explore the potential neuroprotective effects of nilvadipine, particularly in the context of Alzheimer's disease. Some studies suggest that nilvadipine may help reduce cerebral blood flow abnormalities and amyloid beta accumulation, which are characteristic of Alzheimer's disease. However, more research is needed to fully understand its efficacy and safety in this context.
