Mitochondrial myopathy: Difference between revisions
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
{{SI}} | |||
{{Infobox medical condition | |||
| name = Mitochondrial myopathy | |||
| image = [[File:Animal_mitochondrion_diagram_en_(edit).svg|250px]] | |||
| caption = Diagram of a mitochondrion | |||
| synonyms = | |||
| pronounce = | |||
| specialty = [[Neurology]], [[Genetics]] | |||
| symptoms = [[Muscle weakness]], [[Exercise intolerance]], [[Fatigue (medical)]], [[Hearing loss]], [[Cardiomyopathy]] | |||
| onset = Varies, often in [[childhood]] or [[adolescence]] | |||
| duration = Long-term | |||
| causes = Mutations in [[mitochondrial DNA]] or [[nuclear DNA]] affecting [[mitochondrial function]] | |||
| risks = | |||
| diagnosis = [[Muscle biopsy]], [[Genetic testing]], [[Blood tests]] | |||
| differential = [[Muscular dystrophy]], [[Metabolic myopathy]] | |||
| treatment = [[Supportive care]], [[Physical therapy]], [[Coenzyme Q10]] supplementation | |||
| medication = | |||
| prognosis = Variable, depends on specific mutation and severity | |||
| frequency = Rare | |||
| deaths = | |||
}} | |||
[[File:Mitochondrial_inheritance.svg|Diagram of mitochondrial inheritance|thumb|left]] | |||
[[File:Ragged_red_fibres_-_gtc_-_very_high_mag.jpg|Ragged red fibers under very high magnification|thumb|left]] | |||
'''Mitochondrial myopathy''' is a type of [[myopathy]] associated with [[mitochondria|mitochondrial disease]]. It is a neuromuscular disease characterized by muscle weakness, exercise intolerance, and fatigue. It is caused by genetic mutations that affect the function of the mitochondria, the energy-producing structures within cells. | '''Mitochondrial myopathy''' is a type of [[myopathy]] associated with [[mitochondria|mitochondrial disease]]. It is a neuromuscular disease characterized by muscle weakness, exercise intolerance, and fatigue. It is caused by genetic mutations that affect the function of the mitochondria, the energy-producing structures within cells. | ||
== Symptoms == | == Symptoms == | ||
The symptoms of mitochondrial myopathy can vary greatly from person to person. They may include muscle weakness, fatigue, exercise intolerance, and difficulty with physical coordination. Some people may also experience heart problems, diabetes, and gastrointestinal disorders. In severe cases, the disease can lead to life-threatening complications such as heart failure and respiratory failure. | The symptoms of mitochondrial myopathy can vary greatly from person to person. They may include muscle weakness, fatigue, exercise intolerance, and difficulty with physical coordination. Some people may also experience heart problems, diabetes, and gastrointestinal disorders. In severe cases, the disease can lead to life-threatening complications such as heart failure and respiratory failure. | ||
== Causes == | == Causes == | ||
Mitochondrial myopathy is caused by genetic mutations that affect the function of the mitochondria. These mutations can be inherited from one or both parents, or they can occur spontaneously. The mutations cause the mitochondria to produce less energy than normal, which can lead to muscle weakness and other symptoms. | Mitochondrial myopathy is caused by genetic mutations that affect the function of the mitochondria. These mutations can be inherited from one or both parents, or they can occur spontaneously. The mutations cause the mitochondria to produce less energy than normal, which can lead to muscle weakness and other symptoms. | ||
== Diagnosis == | == Diagnosis == | ||
The diagnosis of mitochondrial myopathy is often challenging due to the wide range of symptoms and the fact that many other conditions can cause similar symptoms. Doctors may use a combination of medical history, physical examination, and laboratory tests to diagnose the condition. These tests may include blood tests, muscle biopsy, and genetic testing. | The diagnosis of mitochondrial myopathy is often challenging due to the wide range of symptoms and the fact that many other conditions can cause similar symptoms. Doctors may use a combination of medical history, physical examination, and laboratory tests to diagnose the condition. These tests may include blood tests, muscle biopsy, and genetic testing. | ||
== Treatment == | == Treatment == | ||
There is currently no cure for mitochondrial myopathy, but treatment can help manage symptoms and improve quality of life. Treatment options may include physical therapy, medication, and in some cases, surgery. Lifestyle changes such as regular exercise and a healthy diet can also help manage symptoms. | There is currently no cure for mitochondrial myopathy, but treatment can help manage symptoms and improve quality of life. Treatment options may include physical therapy, medication, and in some cases, surgery. Lifestyle changes such as regular exercise and a healthy diet can also help manage symptoms. | ||
== See also == | == See also == | ||
* [[Mitochondrial disease]] | * [[Mitochondrial disease]] | ||
* [[Myopathy]] | * [[Myopathy]] | ||
* [[Genetic disorder]] | * [[Genetic disorder]] | ||
[[Category:Neuromuscular disorders]] | [[Category:Neuromuscular disorders]] | ||
[[Category:Mitochondrial diseases]] | [[Category:Mitochondrial diseases]] | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 21:22, 9 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Mitochondrial myopathy | |
|---|---|
.svg)
| |
| Synonyms | |
| Pronounce | |
| Specialty | Neurology, Genetics |
| Symptoms | Muscle weakness, Exercise intolerance, Fatigue (medical), Hearing loss, Cardiomyopathy |
| Complications | N/A |
| Onset | Varies, often in childhood or adolescence |
| Duration | Long-term |
| Types | N/A |
| Causes | Mutations in mitochondrial DNA or nuclear DNA affecting mitochondrial function |
| Risks | |
| Diagnosis | Muscle biopsy, Genetic testing, Blood tests |
| Differential diagnosis | Muscular dystrophy, Metabolic myopathy |
| Prevention | N/A |
| Treatment | Supportive care, Physical therapy, Coenzyme Q10 supplementation |
| Medication | |
| Prognosis | Variable, depends on specific mutation and severity |
| Frequency | Rare |
| Deaths | |
Mitochondrial myopathy is a type of myopathy associated with mitochondrial disease. It is a neuromuscular disease characterized by muscle weakness, exercise intolerance, and fatigue. It is caused by genetic mutations that affect the function of the mitochondria, the energy-producing structures within cells.
Symptoms[edit]
The symptoms of mitochondrial myopathy can vary greatly from person to person. They may include muscle weakness, fatigue, exercise intolerance, and difficulty with physical coordination. Some people may also experience heart problems, diabetes, and gastrointestinal disorders. In severe cases, the disease can lead to life-threatening complications such as heart failure and respiratory failure.
Causes[edit]
Mitochondrial myopathy is caused by genetic mutations that affect the function of the mitochondria. These mutations can be inherited from one or both parents, or they can occur spontaneously. The mutations cause the mitochondria to produce less energy than normal, which can lead to muscle weakness and other symptoms.
Diagnosis[edit]
The diagnosis of mitochondrial myopathy is often challenging due to the wide range of symptoms and the fact that many other conditions can cause similar symptoms. Doctors may use a combination of medical history, physical examination, and laboratory tests to diagnose the condition. These tests may include blood tests, muscle biopsy, and genetic testing.
Treatment[edit]
There is currently no cure for mitochondrial myopathy, but treatment can help manage symptoms and improve quality of life. Treatment options may include physical therapy, medication, and in some cases, surgery. Lifestyle changes such as regular exercise and a healthy diet can also help manage symptoms.
