Haloxon: Difference between revisions

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[[File:Haloxon.svg|thumb|{{PAGENAME}}]] <br>'''Haloxon''' is an [[organophosphate]] compound that is used as an [[anthelmintic]] agent. It is primarily used in veterinary medicine to treat parasitic worm infections in livestock.
{{Infobox drug
| name = Haloxon
| image = Haloxon.svg
| image_size = 200px
| alt = Chemical structure of Haloxon
| caption = Chemical structure of Haloxon
| tradename =
| synonyms =
| IUPAC_name = [[IUPAC name of Haloxon]]
| CAS_number = 321-55-1
| ATC_prefix =
| ATC_suffix =
| PubChem = 16683
| DrugBank =
| ChemSpiderID = 15819
| UNII =
| KEGG =
| ChEBI =
| ChEMBL =
| C=9
| H=14
| Cl=1
| O=4
| P=1
}}


==Chemistry==
'''Haloxon''' is an organophosphate compound that has been used as an [[anthelmintic]] agent, particularly in veterinary medicine. It is primarily used to treat parasitic infections in animals, such as [[helminthiasis]] in livestock.
Haloxon is a derivative of [[chloroxuron]], a type of organophosphate. It is synthesized by the reaction of chloroxuron with [[sodium hydroxide]] and [[hydrogen peroxide]]. The resulting compound is a white crystalline powder that is soluble in water and most organic solvents.


==Pharmacology==
==Chemical Structure and Properties==
As an anthelmintic, Haloxon works by inhibiting the enzyme [[acetylcholinesterase]] in parasitic worms. This causes an accumulation of [[acetylcholine]] in the worm's nervous system, leading to paralysis and death of the parasite. Haloxon is effective against a variety of parasitic worms, including [[nematodes]], [[cestodes]], and [[trematodes]].
[[File:Haloxon.svg|thumb|Chemical structure of Haloxon]]
Haloxon is characterized by its organophosphate structure, which includes a phosphorus atom bonded to an oxygen atom and a chlorine atom. The chemical formula for Haloxon is C₉H₁₄ClO₄P, and it has a molecular weight of approximately 252.63 g/mol.


==Usage==
==Mechanism of Action==
Haloxon is primarily used in veterinary medicine to treat parasitic worm infections in livestock. It is administered orally, usually in the form of a drench. The dosage varies depending on the type and size of the animal, as well as the severity of the infection.
Haloxon functions by inhibiting the enzyme [[acetylcholinesterase]], which is crucial for the breakdown of the neurotransmitter [[acetylcholine]] in the synaptic cleft. By inhibiting this enzyme, Haloxon causes an accumulation of acetylcholine, leading to continuous stimulation of muscles, paralysis, and eventual death of the parasitic worms.


==Safety==
==Uses in Veterinary Medicine==
Like other organophosphates, Haloxon can be toxic if ingested or absorbed through the skin. It can cause a variety of symptoms in humans, including nausea, vomiting, diarrhea, and in severe cases, seizures or death. Proper protective equipment should be used when handling Haloxon, and it should be stored in a secure location out of reach of children and pets.
Haloxon is used to treat a variety of parasitic infections in animals, particularly in cattle, sheep, and goats. It is effective against a range of gastrointestinal nematodes and is often administered as part of a broader parasite control program.


==See also==
==Safety and Toxicity==
As with other organophosphates, Haloxon can be toxic to non-target species, including humans, if not used properly. It is important to follow recommended dosages and safety guidelines to minimize the risk of toxicity. Symptoms of organophosphate poisoning include muscle twitching, weakness, respiratory distress, and, in severe cases, death.
 
==Regulation and Approval==
The use of Haloxon is regulated by veterinary health authorities, and it is important to adhere to local regulations regarding its use in livestock. Withdrawal periods must be observed to ensure that residues do not remain in meat or milk intended for human consumption.
 
==Also see==
* [[Organophosphate]]
* [[Organophosphate]]
* [[Anthelmintic]]
* [[Anthelmintic]]
* [[Chloroxuron]]
* [[Acetylcholinesterase inhibitor]]
* [[Helminthiasis]]
 
{{Drug-stub}}


[[Category:Organophosphates]]
[[Category:Organophosphates]]
[[Category:Anthelmintics]]
[[Category:Anthelmintics]]
[[Category:Veterinary drugs]]
[[Category:Veterinary drugs]]
{{Organophosphates}}
{{Anthelmintics}}
{{Veterinary medicine-stub}}

Latest revision as of 00:49, 10 December 2024

Haloxon
Chemical structure of Haloxon
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number 321-55-1
PubChem 16683
DrugBank
ChemSpider 15819
KEGG


Haloxon is an organophosphate compound that has been used as an anthelmintic agent, particularly in veterinary medicine. It is primarily used to treat parasitic infections in animals, such as helminthiasis in livestock.

Chemical Structure and Properties[edit]

File:Haloxon.svg
Chemical structure of Haloxon

Haloxon is characterized by its organophosphate structure, which includes a phosphorus atom bonded to an oxygen atom and a chlorine atom. The chemical formula for Haloxon is C₉H₁₄ClO₄P, and it has a molecular weight of approximately 252.63 g/mol.

Mechanism of Action[edit]

Haloxon functions by inhibiting the enzyme acetylcholinesterase, which is crucial for the breakdown of the neurotransmitter acetylcholine in the synaptic cleft. By inhibiting this enzyme, Haloxon causes an accumulation of acetylcholine, leading to continuous stimulation of muscles, paralysis, and eventual death of the parasitic worms.

Uses in Veterinary Medicine[edit]

Haloxon is used to treat a variety of parasitic infections in animals, particularly in cattle, sheep, and goats. It is effective against a range of gastrointestinal nematodes and is often administered as part of a broader parasite control program.

Safety and Toxicity[edit]

As with other organophosphates, Haloxon can be toxic to non-target species, including humans, if not used properly. It is important to follow recommended dosages and safety guidelines to minimize the risk of toxicity. Symptoms of organophosphate poisoning include muscle twitching, weakness, respiratory distress, and, in severe cases, death.

Regulation and Approval[edit]

The use of Haloxon is regulated by veterinary health authorities, and it is important to adhere to local regulations regarding its use in livestock. Withdrawal periods must be observed to ensure that residues do not remain in meat or milk intended for human consumption.

Also see[edit]

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