Naringenin: Difference between revisions
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{{DISPLAYTITLE:Naringenin}} | |||
== | == Naringenin == | ||
Naringenin is | [[File:Naringenin.svg|thumb|right|Chemical structure of naringenin]] | ||
'''Naringenin''' is a [[flavanone]], a type of [[flavonoid]] found in various [[citrus]] fruits. It is a colorless, water-insoluble solid that is considered to have various [[health benefits]] due to its [[antioxidant]] properties. | |||
== | == Chemical Properties == | ||
Naringenin has | Naringenin has the chemical formula C<sub>15</sub>H<sub>12</sub>O<sub>5</sub>. It is a derivative of [[flavanone]] and is structurally related to other flavonoids such as [[hesperetin]] and [[quercetin]]. The compound is characterized by its three-ring structure, which includes a [[phenyl]] group and a [[chroman]] ring. | ||
== Sources == | |||
Naringenin is predominantly found in [[citrus fruits]] such as [[grapefruit]], [[oranges]], and [[lemons]]. It is also present in smaller amounts in other fruits like [[tomatoes]] and [[figs]]. The concentration of naringenin can vary depending on the type of fruit and its ripeness. | |||
== | == Biological Effects == | ||
Naringenin is known for its potential [[antioxidant]], [[anti-inflammatory]], and [[anticancer]] properties. It has been studied for its ability to modulate [[enzyme]] activity, particularly in the [[liver]], where it can influence the [[metabolism]] of [[lipids]] and [[carbohydrates]]. | |||
== | === Antioxidant Activity === | ||
As an antioxidant, naringenin helps to neutralize [[free radicals]] in the body, which can prevent [[cellular damage]] and reduce the risk of [[chronic diseases]] such as [[cardiovascular disease]] and [[cancer]]. | |||
[[ | === Anti-inflammatory Effects === | ||
[[ | Naringenin has been shown to reduce [[inflammation]] by inhibiting the production of [[pro-inflammatory cytokines]]. This makes it a compound of interest in the treatment of [[inflammatory diseases]] such as [[arthritis]] and [[asthma]]. | ||
[[ | |||
=== Anticancer Potential === | |||
Research suggests that naringenin may have anticancer properties by inducing [[apoptosis]] in [[cancer cells]] and inhibiting their proliferation. It has been studied in various types of cancer, including [[breast cancer]], [[prostate cancer]], and [[colon cancer]]. | |||
== Metabolism == | |||
Naringenin is metabolized in the human body primarily in the [[liver]]. It undergoes [[phase II metabolism]], where it is conjugated with [[glucuronic acid]] or [[sulfate]] to form more water-soluble metabolites that can be excreted in the [[urine]]. | |||
== | == Potential Health Benefits == | ||
Due to its various biological activities, naringenin is being investigated for its potential health benefits, including its role in improving [[cardiovascular health]], managing [[diabetes]], and supporting [[weight loss]]. | |||
== | == Related Pages == | ||
* [ | * [[Flavonoid]] | ||
* [ | * [[Antioxidant]] | ||
* [[Citrus]] | |||
* [[Metabolism]] | |||
[[Category:Flavonoids]] | |||
[[Category:Antioxidants]] | |||
[[Category:Phytochemicals]] | |||
Latest revision as of 04:01, 13 February 2025
Naringenin[edit]
Naringenin is a flavanone, a type of flavonoid found in various citrus fruits. It is a colorless, water-insoluble solid that is considered to have various health benefits due to its antioxidant properties.
Chemical Properties[edit]
Naringenin has the chemical formula C15H12O5. It is a derivative of flavanone and is structurally related to other flavonoids such as hesperetin and quercetin. The compound is characterized by its three-ring structure, which includes a phenyl group and a chroman ring.
Sources[edit]
Naringenin is predominantly found in citrus fruits such as grapefruit, oranges, and lemons. It is also present in smaller amounts in other fruits like tomatoes and figs. The concentration of naringenin can vary depending on the type of fruit and its ripeness.
Biological Effects[edit]
Naringenin is known for its potential antioxidant, anti-inflammatory, and anticancer properties. It has been studied for its ability to modulate enzyme activity, particularly in the liver, where it can influence the metabolism of lipids and carbohydrates.
Antioxidant Activity[edit]
As an antioxidant, naringenin helps to neutralize free radicals in the body, which can prevent cellular damage and reduce the risk of chronic diseases such as cardiovascular disease and cancer.
Anti-inflammatory Effects[edit]
Naringenin has been shown to reduce inflammation by inhibiting the production of pro-inflammatory cytokines. This makes it a compound of interest in the treatment of inflammatory diseases such as arthritis and asthma.
Anticancer Potential[edit]
Research suggests that naringenin may have anticancer properties by inducing apoptosis in cancer cells and inhibiting their proliferation. It has been studied in various types of cancer, including breast cancer, prostate cancer, and colon cancer.
Metabolism[edit]
Naringenin is metabolized in the human body primarily in the liver. It undergoes phase II metabolism, where it is conjugated with glucuronic acid or sulfate to form more water-soluble metabolites that can be excreted in the urine.
Potential Health Benefits[edit]
Due to its various biological activities, naringenin is being investigated for its potential health benefits, including its role in improving cardiovascular health, managing diabetes, and supporting weight loss.
