Nitroxinil: Difference between revisions

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'''Nitroxinil''' is a [[chemical compound]] used as an [[anthelmintic]]. It is specifically used to treat [[Fasciola hepatica]] infections in cattle and sheep. Nitroxinil is a halogenated phenolic compound with a nitro group at the 4-position.
{{Short description|An anthelmintic drug used in veterinary medicine}}
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==Chemical Properties==
'''Nitroxinil''' is a chemical compound used as an [[anthelmintic]] in veterinary medicine. It is primarily used to treat infections caused by [[liver flukes]] and other parasitic worms in livestock.
Nitroxinil is a yellowish, crystalline powder. It is slightly soluble in water and freely soluble in most organic solvents. The chemical formula for nitroxinil is C7H3Cl2NO3 and its molecular weight is 230.01 g/mol.


==Pharmacology==
==Chemical properties==
Nitroxinil is a [[flukicide]], meaning it is used to kill liver flukes. It works by inhibiting the fluke's ability to metabolize glucose, which is their primary source of energy. This causes the fluke to become immobilized and eventually die.
Nitroxinil is a halogenated phenol derivative. Its chemical structure includes a nitro group and an iodine atom, which contribute to its anthelmintic properties. The presence of these groups allows nitroxinil to interfere with the metabolic processes of parasites, leading to their death.


==Usage==
==Mechanism of action==
Nitroxinil is administered orally to cattle and sheep. The recommended dosage is 10 mg/kg body weight for cattle and 7.5 mg/kg body weight for sheep. It is important to note that nitroxinil should not be used in animals with known hypersensitivity to the drug.
Nitroxinil works by uncoupling oxidative phosphorylation in the mitochondria of parasites. This action disrupts the energy metabolism of the parasites, leading to a depletion of ATP and eventual death. The drug is particularly effective against [[Fasciola hepatica]], the common liver fluke, which affects the liver of various livestock animals.


==Side Effects==
==Usage in veterinary medicine==
Possible side effects of nitroxinil include [[anorexia]], [[diarrhea]], and [[abdominal pain]]. In rare cases, nitroxinil can cause [[jaundice]] and [[hepatotoxicity]].
In veterinary practice, nitroxinil is administered to cattle, sheep, and goats to control liver fluke infections. It is often used in areas where liver fluke infections are endemic and can cause significant economic losses in livestock production. The drug is typically administered via subcutaneous injection.


==Precautions==
==Safety and precautions==
Nitroxinil should not be used in animals with known hypersensitivity to the drug. It should also not be used in animals with severe liver disease. Pregnant and lactating animals should only be treated with nitroxinil under the supervision of a veterinarian.
While nitroxinil is effective in treating parasitic infections, it must be used with caution. Overdosage can lead to toxicity in animals, and there are specific withdrawal periods that must be observed before the meat or milk from treated animals can be consumed by humans. It is important for veterinarians to follow the recommended dosage and administration guidelines to ensure the safety of the animals and the food supply.


==See Also==
==Related pages==
* [[Anthelmintic]]
* [[Anthelmintic]]
* [[Fasciola hepatica]]
* [[Liver fluke]]
* [[Flukicide]]
* [[Veterinary medicine]]


[[Category:Chemical Compounds]]
[[Category:Anthelmintics]]
[[Category:Pharmacology]]
[[Category:Veterinary drugs]]
[[Category:Veterinary Medicine]]
 
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Revision as of 11:04, 15 February 2025

An anthelmintic drug used in veterinary medicine


Nitroxinil
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Nitroxinil is a chemical compound used as an anthelmintic in veterinary medicine. It is primarily used to treat infections caused by liver flukes and other parasitic worms in livestock.

Chemical properties

Nitroxinil is a halogenated phenol derivative. Its chemical structure includes a nitro group and an iodine atom, which contribute to its anthelmintic properties. The presence of these groups allows nitroxinil to interfere with the metabolic processes of parasites, leading to their death.

Mechanism of action

Nitroxinil works by uncoupling oxidative phosphorylation in the mitochondria of parasites. This action disrupts the energy metabolism of the parasites, leading to a depletion of ATP and eventual death. The drug is particularly effective against Fasciola hepatica, the common liver fluke, which affects the liver of various livestock animals.

Usage in veterinary medicine

In veterinary practice, nitroxinil is administered to cattle, sheep, and goats to control liver fluke infections. It is often used in areas where liver fluke infections are endemic and can cause significant economic losses in livestock production. The drug is typically administered via subcutaneous injection.

Safety and precautions

While nitroxinil is effective in treating parasitic infections, it must be used with caution. Overdosage can lead to toxicity in animals, and there are specific withdrawal periods that must be observed before the meat or milk from treated animals can be consumed by humans. It is important for veterinarians to follow the recommended dosage and administration guidelines to ensure the safety of the animals and the food supply.

Related pages