Methylergometrine: Difference between revisions
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{{Short description|A medication used to prevent or control excessive bleeding following childbirth}} | |||
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'''Methylergometrine''', also known as '''methylergonovine''', is a medication used to prevent or control excessive bleeding following childbirth. It is a [[uterotonic]] agent that works by increasing the tone, rate, and amplitude of contractions of the smooth muscle of the uterus. | |||
Methylergometrine is | |||
== | ==Pharmacology== | ||
Methylergometrine is a [[semisynthetic]] [[ergot alkaloid]] derivative. It acts as a partial agonist on [[serotonin]] and [[dopamine]] receptors, and as an antagonist on [[alpha-adrenergic receptors]]. This action results in the contraction of uterine smooth muscle, which helps to reduce postpartum hemorrhage. | |||
== | ==Medical uses== | ||
Methylergometrine | Methylergometrine is primarily used in the management of the third stage of labor and the prevention and treatment of postpartum hemorrhage. It is administered either orally or by injection, depending on the clinical situation. | ||
== | ==Side effects== | ||
Common side effects of methylergometrine include [[nausea]], [[vomiting]], [[hypertension]], and [[headache]]. In rare cases, it can cause [[seizures]] or [[myocardial infarction]]. | |||
== Contraindications == | ==Contraindications== | ||
Methylergometrine is contraindicated in patients with | Methylergometrine is contraindicated in patients with [[hypertension]], [[preeclampsia]], or [[eclampsia]]. It should also be avoided in patients with a history of [[coronary artery disease]] or [[peripheral vascular disease]]. | ||
== | ==Mechanism of action== | ||
Methylergometrine | Methylergometrine works by stimulating the smooth muscle of the uterus to contract. This is achieved through its action on various receptors, including [[serotonin receptors]] and [[alpha-adrenergic receptors]]. The increased uterine tone and contractions help to reduce bleeding by compressing the blood vessels in the uterine wall. | ||
== | ==Administration== | ||
Methylergometrine can be administered orally, intramuscularly, or intravenously. The route of administration depends on the urgency of the situation and the clinical judgment of the healthcare provider. | |||
== | ==Related pages== | ||
* [[Postpartum hemorrhage]] | |||
* [[Uterotonic]] | |||
* [[Ergot alkaloid]] | |||
[[Category:Obstetrics]] | [[Category:Obstetrics]] | ||
[[Category: | [[Category:Drugs]] | ||
[[Category:Ergot alkaloids]] | |||
Revision as of 11:08, 15 February 2025
A medication used to prevent or control excessive bleeding following childbirth
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Methylergometrine, also known as methylergonovine, is a medication used to prevent or control excessive bleeding following childbirth. It is a uterotonic agent that works by increasing the tone, rate, and amplitude of contractions of the smooth muscle of the uterus.
Pharmacology
Methylergometrine is a semisynthetic ergot alkaloid derivative. It acts as a partial agonist on serotonin and dopamine receptors, and as an antagonist on alpha-adrenergic receptors. This action results in the contraction of uterine smooth muscle, which helps to reduce postpartum hemorrhage.
Medical uses
Methylergometrine is primarily used in the management of the third stage of labor and the prevention and treatment of postpartum hemorrhage. It is administered either orally or by injection, depending on the clinical situation.
Side effects
Common side effects of methylergometrine include nausea, vomiting, hypertension, and headache. In rare cases, it can cause seizures or myocardial infarction.
Contraindications
Methylergometrine is contraindicated in patients with hypertension, preeclampsia, or eclampsia. It should also be avoided in patients with a history of coronary artery disease or peripheral vascular disease.
Mechanism of action
Methylergometrine works by stimulating the smooth muscle of the uterus to contract. This is achieved through its action on various receptors, including serotonin receptors and alpha-adrenergic receptors. The increased uterine tone and contractions help to reduce bleeding by compressing the blood vessels in the uterine wall.
Administration
Methylergometrine can be administered orally, intramuscularly, or intravenously. The route of administration depends on the urgency of the situation and the clinical judgment of the healthcare provider.
