Valnemulin: Difference between revisions

Valnemulin
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Revision as of 11:59, 9 February 2025

An antibiotic used in veterinary medicine

Valnemulin is a pleuromutilin antibiotic used in veterinary medicine primarily for the treatment of swine and poultry diseases. It is effective against a range of Gram-positive and some Gram-negative bacteria, as well as mycoplasma infections.

Mechanism of action

Valnemulin works by inhibiting bacterial protein synthesis. It binds to the 50S subunit of the bacterial ribosome, thereby preventing the formation of peptide bonds and halting the growth of the bacteria. This mechanism is similar to that of other pleuromutilin antibiotics.

Uses

Valnemulin is primarily used in the treatment of swine dysentery, caused by Brachyspira hyodysenteriae, and enzootic pneumonia in pigs, caused by Mycoplasma hyopneumoniae. It is also used to control necrotic enteritis in poultry, which is caused by Clostridium perfringens.

Administration

Valnemulin is administered orally, often mixed with feed or water, to ensure proper dosage and distribution among livestock. The dosage and duration of treatment depend on the specific disease being treated and the severity of the infection.

Side effects

While generally well-tolerated, valnemulin can cause some side effects in animals, including gastrointestinal disturbances. Overuse or misuse can lead to the development of antibiotic resistance, which is a significant concern in veterinary medicine.

Regulation and approval

Valnemulin is approved for use in many countries, subject to regulations that ensure its safe and effective use in food-producing animals. It is important to adhere to withdrawal periods to ensure that residues do not remain in meat products intended for human consumption.

Related pages

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-'''Valnemulin''' is an [[antibiotic]] that belongs to the [[pleuromutilin]] class of antibiotics. It is primarily used in veterinary medicine to treat [[swine dysentery]] and [[ileitis]], diseases caused by [[bacteria]] in pigs.
+{{Short description|An antibiotic used in veterinary medicine}}
+{{Drugbox
+| verifiedrevid = 477241123
+| image = Valnemulin.svg
+| image_size = 200px
+}}
-==Etymology==
+'''Valnemulin''' is a [[pleuromutilin]] [[antibiotic]] used in [[veterinary medicine]] primarily for the treatment of [[swine]] and [[poultry]] diseases. It is effective against a range of [[Gram-positive bacteria|Gram-positive]] and some [[Gram-negative bacteria|Gram-negative]] bacteria, as well as [[mycoplasma]] infections.
-The term "Valnemulin" is derived from the class of antibiotics it belongs to, pleuromutilin, and the specific chemical structure of the compound. The "val" prefix is likely a reference to the valeric acid component of the molecule, while "nemulin" is a derivative of pleuromutilin.
-==Usage==
+==Mechanism of action==
-Valnemulin is used in the treatment of swine dysentery and ileitis, both of which are bacterial infections in pigs. Swine dysentery, caused by ''[[Brachyspira hyodysenteriae]]'', is a severe, contagious disease that affects the large intestine of pigs, causing severe diarrhea and weight loss. Ileitis, also known as porcine proliferative enteropathy, is caused by ''[[Lawsonia intracellularis]]'' and affects the small intestine, causing diarrhea, reduced growth rate, and in severe cases, death.
+Valnemulin works by inhibiting bacterial [[protein synthesis]]. It binds to the 50S subunit of the bacterial [[ribosome]], thereby preventing the formation of peptide bonds and halting the growth of the bacteria. This mechanism is similar to that of other pleuromutilin antibiotics.
-Valnemulin works by inhibiting the synthesis of bacterial proteins, which are essential for the bacteria's growth and reproduction. This makes it an effective treatment for bacterial infections.
+==Uses==
+Valnemulin is primarily used in the treatment of [[swine dysentery]], caused by ''[[Brachyspira hyodysenteriae]]'', and [[enzootic pneumonia]] in pigs, caused by ''[[Mycoplasma hyopneumoniae]]''. It is also used to control [[necrotic enteritis]] in poultry, which is caused by ''[[Clostridium perfringens]]''.
-==Side Effects==
+==Administration==
-As with all antibiotics, use of valnemulin can lead to the development of [[antibiotic resistance]] in bacteria. This is a major concern in both human and veterinary medicine, as it can make infections more difficult to treat. Other potential side effects include digestive disturbances, such as diarrhea and loss of appetite.
+Valnemulin is administered orally, often mixed with feed or water, to ensure proper dosage and distribution among livestock. The dosage and duration of treatment depend on the specific disease being treated and the severity of the infection.
-==Related Terms==
+==Side effects==
-* [[Antibiotic]]
+While generally well-tolerated, valnemulin can cause some side effects in animals, including [[gastrointestinal]] disturbances. Overuse or misuse can lead to the development of [[antibiotic resistance]], which is a significant concern in veterinary medicine.
+==Regulation and approval==
+Valnemulin is approved for use in many countries, subject to regulations that ensure its safe and effective use in food-producing animals. It is important to adhere to withdrawal periods to ensure that residues do not remain in meat products intended for human consumption.
+==Related pages==
 * [[Pleuromutilin]]
-* [[Swine dysentery]]
-* [[Ileitis]]
-* [[Brachyspira hyodysenteriae]]
-* [[Lawsonia intracellularis]]
 * [[Antibiotic resistance]]
+* [[Veterinary medicine]]
-==References==
-<references />
 [[Category:Antibiotics]]
 [[Category:Veterinary drugs]]
-[[Category:Pleuromutilins]]
-{{stub}}