Plasminogen (medication): Difference between revisions

Plasminogen (medication)
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Latest revision as of 16:48, 29 December 2024

Plasminogen is a medication used in the treatment of certain medical conditions related to fibrinolysis. It is a precursor to plasmin, an important enzyme that breaks down fibrin clots. This medication is primarily used in the management of hypoplasminogenemia, a rare condition characterized by low levels of plasminogen in the blood.

Mechanism of Action[edit]

Plasminogen is converted into its active form, plasmin, by tissue plasminogen activator (tPA) or urokinase. Plasmin then degrades fibrin, a key component of blood clots, into soluble fragments. This process is crucial for the maintenance of normal blood flow and prevention of thrombosis.

Indications[edit]

Plasminogen is indicated for use in patients with congenital plasminogen deficiency, which can lead to the development of ligneous conjunctivitis, a condition characterized by the formation of wood-like pseudomembranes on the conjunctiva.

Administration[edit]

Plasminogen is administered via intravenous infusion. The dosage and frequency depend on the severity of the deficiency and the clinical response of the patient.

Side Effects[edit]

Common side effects of plasminogen therapy may include allergic reactions, fever, and headache. Serious side effects are rare but can include anaphylaxis and thrombosis.

Contraindications[edit]

Plasminogen should not be used in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with active bleeding disorders.

References[edit]

External Links[edit]

Plasminogen on WikiMD

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-== Plasminogen (medication) ==
-[[File:Plasminogen_structure.png|thumb|right|200px|Structure of Plasminogen]]
+{{Infobox drug
+| name = Plasminogen
+| image = <!-- Image of the drug -->
+| width =
+| alt =
+| caption =
+| pronounce =
+| tradename =
+| Drugs.com =
+| MedlinePlus =
+| pregnancy_AU =
+| pregnancy_US =
+| pregnancy_category =
+| legal_AU =
+| legal_CA =
+| legal_UK =
+| legal_US =
+| legal_status =
+| routes_of_administration =
+| bioavailability =
+| protein_bound =
+| metabolism =
+| elimination_half-life =
+| excretion =
+| CAS_number =
+| ATC_prefix =
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+| PubChem =
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+| KEGG =
+| ChEBI =
+| ChEMBL =
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+}}
-'''Plasminogen''' is a medication used in the treatment of certain medical conditions related to blood clotting. It is a naturally occurring protein found in the blood that plays a crucial role in the breakdown of blood clots. Plasminogen is converted into an enzyme called plasmin, which helps dissolve fibrin, the main component of blood clots. This medication is primarily used in cases where there is an excessive formation of blood clots or when the body's natural clot-dissolving mechanisms are impaired.
+'''Plasminogen''' is a [[medication]] used in the treatment of certain medical conditions related to [[fibrinolysis]]. It is a precursor to [[plasmin]], an important enzyme that breaks down [[fibrin]] clots. This medication is primarily used in the management of [[hypoplasminogenemia]], a rare condition characterized by low levels of plasminogen in the blood.
-=== Mechanism of Action ===
+== Mechanism of Action ==
+Plasminogen is converted into its active form, [[plasmin]], by [[tissue plasminogen activator]] (tPA) or [[urokinase]]. Plasmin then degrades fibrin, a key component of blood clots, into soluble fragments. This process is crucial for the maintenance of normal blood flow and prevention of [[thrombosis]].
-Plasminogen works by binding to fibrin, the protein that forms the structure of blood clots. Once bound, plasminogen is converted into its active form, plasmin, by an enzyme called tissue plasminogen activator (tPA). Plasmin then acts to break down the fibrin strands, leading to the dissolution of the blood clot. This process is known as fibrinolysis.
+== Indications ==
+Plasminogen is indicated for use in patients with congenital plasminogen deficiency, which can lead to the development of [[ligneous conjunctivitis]], a condition characterized by the formation of wood-like pseudomembranes on the [[conjunctiva]].
-=== Indications ===
+== Administration ==
+Plasminogen is administered via [[intravenous]] infusion. The dosage and frequency depend on the severity of the deficiency and the clinical response of the patient.
-Plasminogen is primarily used in the treatment of a rare genetic disorder called [[plasminogen deficiency]]. In this condition, the body does not produce enough plasminogen, leading to an increased risk of abnormal blood clot formation. Plasminogen replacement therapy can help prevent or dissolve these clots, reducing the risk of complications such as deep vein thrombosis, pulmonary embolism, or stroke.
+== Side Effects ==
+Common side effects of plasminogen therapy may include [[allergic reactions]], [[fever]], and [[headache]]. Serious side effects are rare but can include [[anaphylaxis]] and [[thrombosis]].
-=== Administration ===
+== Contraindications ==
+Plasminogen should not be used in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with active [[bleeding disorders]].
-Plasminogen is administered intravenously, usually in a hospital or clinical setting. The dosage and duration of treatment depend on the specific condition being treated and the patient's individual needs. The medication is typically given under the supervision of a healthcare professional who is experienced in the management of clotting disorders.
-=== Side Effects ===
-Like any medication, plasminogen may cause side effects in some individuals. Common side effects include headache, nausea, vomiting, and allergic reactions such as rash or itching. Serious side effects are rare but may include bleeding, blood in the urine or stool, or signs of an allergic reaction such as difficulty breathing or swelling of the face, lips, or tongue. It is important to report any unusual or severe side effects to a healthcare professional immediately.
-=== Precautions ===
-Before starting plasminogen therapy, it is important to inform the healthcare provider about any existing medical conditions, allergies, or medications being taken. Plasminogen should be used with caution in individuals with a history of bleeding disorders or those at an increased risk of bleeding. It is also important to monitor blood clotting parameters regularly during treatment to ensure the medication is working effectively and not causing any adverse effects.
-=== Conclusion ===
-Plasminogen is a medication used in the treatment of certain medical conditions related to blood clotting. By promoting the breakdown of blood clots, it helps prevent complications associated with excessive clot formation. While generally well-tolerated, it is important to be aware of potential side effects and to follow the healthcare provider's instructions for safe and effective use of this medication.
 == See Also ==
 * [[Fibrinolysis]]
+* [[Thrombosis]]
 * [[Tissue plasminogen activator]]
-* [[Deep vein thrombosis]]
-* [[Pulmonary embolism]]
-* [[Stroke]]
 == References ==
-. Smith J, et al. Plasminogen replacement therapy for plasminogen deficiency. N Engl J Med. 2019; 380(6): 549-558.
+{{Reflist}}
-. National Institutes of Health. Plasminogen Deficiency. Available at: [https://rarediseases.info.nih.gov/diseases/10979/plasminogen-deficiency]. Accessed on 15th October 2021.<br>{{stub}}
+== External Links ==
+* [https://www.wikimd.com/wiki/Plasminogen_(medication) Plasminogen on WikiMD]
+[[Category:Medications]]
+[[Category:Hematology]]
+[[Category:Enzymes]]
+[[Category:Blood and blood forming organs]]