Mycoplasma hominis

Mycoplasma hominis is a species of bacteria in the genus Mycoplasma, which belongs to the class Mollicutes. Unlike most bacteria, Mycoplasma hominis lacks a cell wall, a characteristic that places it among the smallest self-replicating bacteria and gives it a unique resistance to antibiotics that target cell wall synthesis, such as beta-lactams. Mycoplasma hominis is a facultative anaerobic organism and is part of the normal genital flora in humans, but it can also act as a pathogen in various infections.

Pathogenesis and Clinical Significance

Mycoplasma hominis is associated with several diseases in humans, particularly in the urogenital tract. It can be transmitted sexually and vertically from mother to child during childbirth. The bacterium has been implicated in diseases such as bacterial vaginosis, pelvic inflammatory disease (PID), postpartum fever, and infections of the newborn, including pneumonia and meningitis. Despite its role in these conditions, the pathogenic mechanisms of Mycoplasma hominis are not fully understood, partly due to its commensal presence in some individuals without causing disease.

Diagnosis and Treatment

Diagnosis of Mycoplasma hominis infections can be challenging due to its presence as part of the normal genital flora in some individuals. Culture, nucleic acid amplification tests (NAATs), and serological methods are used for detection. Treatment typically involves antibiotics, but the lack of a cell wall makes Mycoplasma hominis inherently resistant to beta-lactam antibiotics. Tetracyclines and fluoroquinolones are commonly used, but resistance to these antibiotics has been reported, necessitating susceptibility testing for appropriate treatment.

Epidemiology

The prevalence of Mycoplasma hominis varies globally and within different populations. Its presence is more common in sexually active individuals and can be influenced by factors such as age, sexual behavior, and the presence of other sexually transmitted infections (STIs).

Prevention

Prevention of Mycoplasma hominis infections primarily involves safe sexual practices, including the use of condoms. Awareness and education about STIs can also reduce the risk of infection. In pregnant women, screening and treatment may be considered to prevent vertical transmission to the newborn.

Research Directions

Research on Mycoplasma hominis continues to focus on understanding its role in disease, mechanisms of pathogenicity, and resistance to antibiotics. Development of more effective diagnostic methods and treatments is also an area of ongoing study.

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