ACPD: Difference between revisions

Latest revision as of 23:57, 24 February 2025

1-Amino-1,3-dicarboxycyclopentane (ACPD) is a chemical compound that acts as a metabotropic glutamate receptor agonist. It is a cyclopentane derivative with two carboxylic acid groups and an amino group, making it a versatile compound in neuropharmacology.

Chemical Structure[edit]

1-Amino-1,3-dicarboxycyclopentane is characterized by a cyclopentane ring with an amino group at the 1-position and carboxylic acid groups at the 1 and 3 positions. This structure allows it to interact with glutamate receptors, particularly the metabotropic subtype, influencing various neurotransmission pathways.

Mechanism of Action[edit]

ACPD functions primarily as an agonist at metabotropic glutamate receptors (mGluRs). These receptors are G-protein coupled receptors that modulate synaptic transmission and neuroplasticity. By binding to these receptors, ACPD can influence neuronal excitability and synaptic plasticity, playing a role in learning and memory processes.

Applications in Research[edit]

In neuroscience research, ACPD is used to study the role of metabotropic glutamate receptors in the central nervous system. It helps in understanding the mechanisms underlying neurodegenerative diseases, epilepsy, and other neurological disorders. Researchers utilize ACPD to explore the potential therapeutic targets for modulating glutamatergic signaling.

Related Compounds[edit]

ACPD is part of a broader class of compounds known as glutamate analogs. These compounds are used to study the function of glutamate receptors and their role in various physiological and pathological processes.

Related Pages[edit]

1-amino-1,3-dicarboxycyclopentane

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-= 1-Amino-1,3-dicarboxycyclopentane =
+'''1-Amino-1,3-dicarboxycyclopentane''' (ACPD) is a chemical compound that acts as a [[metabotropic glutamate receptor]] agonist. It is a cyclopentane derivative with two carboxylic acid groups and an amino group, making it a versatile compound in [[neuropharmacology]].
--Amino-1,3-dicarboxycyclopentane (ACPD) is a chemical compound that acts as a selective agonist for metabotropic glutamate receptors. It is commonly used in neuroscience research to study the function of these receptors in the central nervous system.
+== Chemical Structure ==
-== Structure and Properties ==
+-Amino-1,3-dicarboxycyclopentane is characterized by a cyclopentane ring with an amino group at the 1-position and carboxylic acid groups at the 1 and 3 positions. This structure allows it to interact with [[glutamate receptors]], particularly the metabotropic subtype, influencing various [[neurotransmission]] pathways.
--Amino-1,3-dicarboxycyclopentane is a cyclopentane derivative with an amino group and two carboxylic acid groups. The presence of these functional groups allows it to interact with [[metabotropic glutamate receptors]], which are a type of [[G protein-coupled receptor]].
 == Mechanism of Action ==
-ACPD acts as an agonist at metabotropic glutamate receptors, specifically targeting the mGluR1 and mGluR5 subtypes. These receptors are involved in modulating synaptic transmission and neuronal excitability. By activating these receptors, ACPD can influence various signaling pathways within the neuron.
+ACPD functions primarily as an agonist at metabotropic glutamate receptors (mGluRs). These receptors are G-protein coupled receptors that modulate [[synaptic transmission]] and [[neuroplasticity]]. By binding to these receptors, ACPD can influence [[neuronal excitability]] and [[synaptic plasticity]], playing a role in learning and memory processes.
 == Applications in Research ==
-In [[neuroscience]] research, ACPD is used to:
+In [[neuroscience]] research, ACPD is used to study the role of metabotropic glutamate receptors in the [[central nervous system]]. It helps in understanding the mechanisms underlying [[neurodegenerative diseases]], [[epilepsy]], and other neurological disorders. Researchers utilize ACPD to explore the potential therapeutic targets for modulating glutamatergic signaling.
-* Investigate the role of metabotropic glutamate receptors in synaptic plasticity, such as [[long-term potentiation]] and [[long-term depression]].
-* Study the involvement of these receptors in [[neurodegenerative diseases]] and [[psychiatric disorders]].
-* Explore the potential therapeutic effects of modulating metabotropic glutamate receptor activity.
-== Safety and Handling ==
+== Related Compounds ==
-As with many research chemicals, proper safety protocols should be followed when handling ACPD. It should be used in a controlled laboratory environment, and appropriate personal protective equipment should be worn.
+ACPD is part of a broader class of compounds known as [[glutamate analogs]]. These compounds are used to study the function of glutamate receptors and their role in various physiological and pathological processes.
 == Related Pages ==
+* [[Glutamate receptor]]
 * [[Metabotropic glutamate receptor]]
 * [[Neurotransmitter]]
 * [[Synaptic plasticity]]
-* [[G protein-coupled receptor]]
-== Gallery ==
+[[Category:Neuropharmacology]]
+[[Category:Glutamate receptor agonists]]
 <gallery>
-File:1-amino-1,3-dicarboxycyclopentane.png|Structure of 1-Amino-1,3-dicarboxycyclopentane
+File:1-amino-1,3-dicarboxycyclopentane.png|1-amino-1,3-dicarboxycyclopentane
 </gallery>
-[[Category:Chemical compounds]]
-[[Category:Neuroscience]]