SB-431542: Difference between revisions
CSV import |
No edit summary |
||
| Line 1: | Line 1: | ||
{{Short description|Chemical compound}} | |||
{{Infobox drug | {{Infobox drug | ||
| image = | | image = SB431542.png | ||
| width = 200 | | width = 200 | ||
| alt = | | alt = | ||
| Line 43: | Line 43: | ||
* [[Stem cell research]] | * [[Stem cell research]] | ||
* [[Cancer research]] | * [[Cancer research]] | ||
[[Category:Chemical compounds]] | [[Category:Chemical compounds]] | ||
[[Category:Biological research]] | [[Category:Biological research]] | ||
| Line 52: | Line 48: | ||
[[Category:Stem cell research]] | [[Category:Stem cell research]] | ||
[[Category:Cancer research]] | [[Category:Cancer research]] | ||
{{medicine-stub}} | {{medicine-stub}} | ||
Latest revision as of 22:27, 13 January 2025
Chemical compound
| SB-431542 | |
|---|---|
| File:SB431542.png | |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | 9945647 |
| DrugBank | |
| ChemSpider | 8120735 |
| KEGG | D10100 |
SB-431542 is a chemical compound that acts as a potent and selective inhibitor of the transforming growth factor beta (TGF-β) type I receptor ALK5. It is widely used in biological research to study the role of TGF-β signaling in various cellular processes.
Mechanism of Action[edit]
SB-431542 inhibits the TGF-β type I receptor ALK5, which is a key component of the TGF-β signaling pathway. By blocking this receptor, SB-431542 prevents the phosphorylation and activation of Smad2 and Smad3, which are downstream effectors in the TGF-β signaling cascade. This inhibition can affect various cellular processes such as cell proliferation, differentiation, and apoptosis.
Applications in Research[edit]
SB-431542 is commonly used in stem cell research to maintain the pluripotency of human embryonic stem cells (hESCs) and to promote the differentiation of induced pluripotent stem cells (iPSCs) into specific cell types. It is also used in cancer research to study the role of TGF-β signaling in tumor progression and metastasis.
Chemical Properties[edit]
SB-431542 has the IUPAC name 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide. It has a molecular formula of C22H16N4O3 and a molecular weight of 384.39 g/mol. The compound is characterized by its benzodioxole and pyridine moieties, which contribute to its biological activity.
Safety and Handling[edit]
As with many chemical compounds used in research, proper safety protocols should be followed when handling SB-431542. It should be stored in a cool, dry place and handled with appropriate personal protective equipment (PPE) to avoid exposure.
See Also[edit]
