Cefovecin: Difference between revisions

Cefovecin
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Latest revision as of 00:51, 20 February 2025

An antibiotic used in veterinary medicine

Cefovecin is a broad-spectrum antibiotic belonging to the cephalosporin class, specifically designed for use in veterinary medicine. It is commonly used to treat bacterial infections in dogs and cats.

Pharmacology[edit]

Cefovecin is a third-generation cephalosporin, which means it has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria. It works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death.

Administration and Dosage[edit]

Cefovecin is administered via subcutaneous injection, typically at a dose of 8 mg/kg. Its long half-life allows for a single injection to provide therapeutic levels for up to 14 days, making it convenient for treating infections in animals that are difficult to medicate orally.

Indications[edit]

Cefovecin is indicated for the treatment of skin infections, urinary tract infections, and soft tissue infections in dogs and cats. It is particularly useful in cases where compliance with oral medication is a concern.

Side Effects[edit]

Common side effects of cefovecin include mild gastrointestinal upset, such as vomiting and diarrhea. In rare cases, allergic reactions may occur, which can manifest as anaphylaxis or skin reactions.

Mechanism of Action[edit]

Cefovecin binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, disrupting the synthesis of peptidoglycan, an essential component of the bacterial cell wall. This leads to the weakening of the cell wall and ultimately causes bacterial cell death.

Resistance[edit]

As with other antibiotics, the use of cefovecin can lead to the development of antibiotic resistance. It is important to use this medication judiciously and only when prescribed by a veterinarian.

Related pages[edit]

Cefovecin

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-'''Cefovecin''' is a long-acting, third-generation cephalosporin antibiotic, used in veterinary medicine. It is primarily indicated for the treatment of skin infections (wounds and abscesses) in cats and dogs, as well as urinary tract infections in dogs. Cefovecin is known for its extended duration of action, typically maintaining therapeutic levels in the plasma for up to 14 days after a single subcutaneous injection. This feature makes it a convenient option for pet owners and veterinarians, as it reduces the need for frequent dosing.
+{{Short description|An antibiotic used in veterinary medicine}}
+{{Drugbox
+| verifiedfields = changed
+| verifiedrevid = 477002313
+| image = Cefovecin.svg
+| image_size = 200px
+| image_alt =
+| image_caption = Chemical structure of Cefovecin
+}}
-==Mechanism of Action==
+'''Cefovecin''' is a broad-spectrum [[antibiotic]] belonging to the [[cephalosporin]] class, specifically designed for use in [[veterinary medicine]]. It is commonly used to treat [[bacterial infections]] in [[dogs]] and [[cats]].
-Cefovecin works by inhibiting the synthesis of the bacterial cell wall, leading to cell death. It does this by binding to and inactivating penicillin-binding proteins (PBPs) located inside the bacterial cell wall. PBPs are enzymes involved in the final stages of assembling the bacterial cell wall and in reshaping the wall during growth and division. By inhibiting these enzymes, cefovecin disrupts the cell wall synthesis, resulting in the bacterium's death.
+==Pharmacology==
+Cefovecin is a third-generation cephalosporin, which means it has a broad spectrum of activity against both [[Gram-positive bacteria|Gram-positive]] and [[Gram-negative bacteria|Gram-negative]] bacteria. It works by inhibiting bacterial [[cell wall]] synthesis, leading to cell lysis and death.
+==Administration and Dosage==
+Cefovecin is administered via [[subcutaneous injection]], typically at a dose of 8 mg/kg. Its long half-life allows for a single injection to provide therapeutic levels for up to 14 days, making it convenient for treating infections in animals that are difficult to medicate orally.
 ==Indications==
-Cefovecin is indicated for the treatment of:
+Cefovecin is indicated for the treatment of skin infections, [[urinary tract infections]], and [[soft tissue infections]] in dogs and cats. It is particularly useful in cases where compliance with oral medication is a concern.
-* [[Skin infections]] (wounds and abscesses) caused by susceptible strains of bacteria in cats and dogs.
-* [[Urinary tract infections]] (UTIs) in dogs, specifically those caused by Escherichia coli and Proteus mirabilis.
-==Pharmacokinetics==
-After a single subcutaneous injection, cefovecin binds extensively to plasma proteins, which contributes to its long duration of action. It is slowly eliminated from the body, primarily through the kidneys. The prolonged therapeutic effect allows for a dosing interval of 14 days, which is significantly longer than that of most other antibiotics.
 ==Side Effects==
-The most common side effects of cefovecin in animals include:
+Common side effects of cefovecin include mild [[gastrointestinal upset]], such as [[vomiting]] and [[diarrhea]]. In rare cases, [[allergic reactions]] may occur, which can manifest as [[anaphylaxis]] or skin reactions.
-* Injection site reactions (such as pain or swelling)
-* Gastrointestinal symptoms (such as vomiting or diarrhea)
-* Allergic reactions, although rare, can occur and may manifest as rash, pruritus, or more severe symptoms requiring immediate veterinary attention.
-==Contraindications==
+==Mechanism of Action==
-Cefovecin should not be used in animals with a known hypersensitivity to cephalosporin antibiotics. Caution is advised when using in animals with a history of allergic reactions to penicillins or other beta-lactam antibiotics, due to the potential for cross-reactivity.
+Cefovecin binds to [[penicillin-binding proteins]] (PBPs) located inside the bacterial cell wall, disrupting the synthesis of [[peptidoglycan]], an essential component of the bacterial cell wall. This leads to the weakening of the cell wall and ultimately causes bacterial cell death.
-==Drug Interactions==
+==Resistance==
-As with all medications, cefovecin may interact with other drugs. It is important to inform the veterinarian about all medications and supplements the pet is receiving before starting treatment with cefovecin.
+As with other antibiotics, the use of cefovecin can lead to the development of [[antibiotic resistance]]. It is important to use this medication judiciously and only when prescribed by a veterinarian.
-==Conclusion==
+==Related pages==
-Cefovecin is a valuable antibiotic in the veterinary field, offering the convenience of a long-acting formulation. Its broad spectrum of activity and extended duration of action make it an effective choice for treating certain bacterial infections in cats and dogs. However, as with all antibiotics, responsible use is crucial to minimize the risk of antibiotic resistance development.
+* [[Cephalosporin]]
+* [[Antibiotic resistance]]
+* [[Veterinary medicine]]
+[[Category:Cephalosporin antibiotics]]
 [[Category:Veterinary drugs]]
-[[Category:Cephalosporin antibiotics]]
+<gallery>
-[[Category:Antibiotics]]
+File:Cefovecin.svg|Cefovecin
+</gallery>
-{{Veterinary-medicine-stub}}