Tenoxicam: Difference between revisions

Latest revision as of 11:01, 15 February 2025

Overview of the nonsteroidal anti-inflammatory drug Tenoxicam

Tenoxicam[edit]

Tenoxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions such as arthritis. It belongs to the oxicam class of NSAIDs, which are known for their long half-life and ability to provide sustained relief from symptoms.

Pharmacology[edit]

Tenoxicam works by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. This inhibition reduces the synthesis of prostaglandins, which are compounds involved in the inflammatory process. By decreasing prostaglandin production, tenoxicam alleviates pain and reduces inflammation.

Mechanism of Action[edit]

The primary mechanism of action of tenoxicam is the inhibition of the COX enzymes. COX-1 is involved in maintaining the normal lining of the stomach, while COX-2 is primarily involved in inflammation. By inhibiting these enzymes, tenoxicam reduces inflammation and pain but may also lead to gastrointestinal side effects due to COX-1 inhibition.

Pharmacokinetics[edit]

Tenoxicam is well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 2 hours after oral administration. It has a long half-life of approximately 72 hours, allowing for once-daily dosing. The drug is extensively bound to plasma proteins and is metabolized in the liver, with excretion primarily via the kidneys.

Clinical Uses[edit]

Tenoxicam is indicated for the treatment of various inflammatory and painful conditions, including:

Side Effects[edit]

Common side effects of tenoxicam include gastrointestinal disturbances such as nausea, dyspepsia, and gastric ulceration. Due to its effect on COX-1, there is a risk of gastrointestinal bleeding, especially in long-term use. Other side effects may include headache, dizziness, and skin rash.

Contraindications[edit]

Tenoxicam is contraindicated in patients with:

Known hypersensitivity to tenoxicam or other NSAIDs
Active peptic ulcer disease
Severe hepatic or renal impairment
History of asthma attacks or allergic reactions after taking aspirin or other NSAIDs

Related pages[edit]

@@ Line 1: / Line 1: @@
-'''Tenoxicam''' is a [[non-steroidal anti-inflammatory drug]] (NSAID) that is used to relieve pain and inflammation in various conditions such as [[arthritis]] and [[gout]]. It works by reducing the production of certain chemicals in the body that cause inflammation and pain.
+{{Short description|Overview of the nonsteroidal anti-inflammatory drug Tenoxicam}}
-== Mechanism of Action ==
+==Tenoxicam==
+[[File:Tenoxicam_FormulaV1.svg|thumb|right|Chemical structure of Tenoxicam]]
+'''Tenoxicam''' is a [[nonsteroidal anti-inflammatory drug]] (NSAID) used to relieve pain and inflammation in conditions such as [[arthritis]]. It belongs to the [[oxicam]] class of NSAIDs, which are known for their long half-life and ability to provide sustained relief from symptoms.
-Tenoxicam belongs to the class of drugs known as [[NSAIDs]]. It works by inhibiting the enzyme [[cyclooxygenase]] (COX), which is involved in the production of [[prostaglandins]]. Prostaglandins are chemicals that promote inflammation, pain, and fever. By reducing the production of these chemicals, Tenoxicam helps to alleviate symptoms associated with inflammatory conditions.
+==Pharmacology==
+Tenoxicam works by inhibiting the [[cyclooxygenase]] (COX) enzymes, specifically COX-1 and COX-2. This inhibition reduces the synthesis of [[prostaglandins]], which are compounds involved in the inflammatory process. By decreasing prostaglandin production, tenoxicam alleviates pain and reduces inflammation.
-== Uses ==
+===Mechanism of Action===
+The primary mechanism of action of tenoxicam is the inhibition of the COX enzymes. COX-1 is involved in maintaining the normal lining of the stomach, while COX-2 is primarily involved in inflammation. By inhibiting these enzymes, tenoxicam reduces inflammation and pain but may also lead to gastrointestinal side effects due to COX-1 inhibition.
-Tenoxicam is used to treat a variety of conditions that cause pain and inflammation, including:
+===Pharmacokinetics===
+Tenoxicam is well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 2 hours after oral administration. It has a long half-life of approximately 72 hours, allowing for once-daily dosing. The drug is extensively bound to plasma proteins and is metabolized in the liver, with excretion primarily via the kidneys.
+==Clinical Uses==
+Tenoxicam is indicated for the treatment of various inflammatory and painful conditions, including:
+* [[Rheumatoid arthritis]]
 * [[Osteoarthritis]]
-* [[Rheumatoid arthritis]]
 * [[Ankylosing spondylitis]]
-* [[Gout]]
+* Acute musculoskeletal disorders
-* [[Musculoskeletal injuries]]
-* [[Postoperative pain]]
-== Side Effects ==
+==Side Effects==
+Common side effects of tenoxicam include gastrointestinal disturbances such as [[nausea]], [[dyspepsia]], and [[gastric ulceration]]. Due to its effect on COX-1, there is a risk of gastrointestinal bleeding, especially in long-term use. Other side effects may include [[headache]], [[dizziness]], and [[skin rash]].
-Like all medications, Tenoxicam can cause side effects. Some of the most common side effects include:
+==Contraindications==
+Tenoxicam is contraindicated in patients with:
+* Known hypersensitivity to tenoxicam or other NSAIDs
+* Active peptic ulcer disease
+* Severe hepatic or renal impairment
+* History of [[asthma]] attacks or allergic reactions after taking aspirin or other NSAIDs
-* [[Nausea]]
+==Related pages==
-* [[Vomiting]]
+* [[Nonsteroidal anti-inflammatory drug]]
-* [[Diarrhea]]
-* [[Stomach pain]]
-* [[Dizziness]]
-* [[Headache]]
-More serious side effects can occur and should be reported to a healthcare provider immediately. These include:
-* [[Chest pain]]
-* [[Shortness of breath]]
-* [[Slurred speech]]
-* [[Weakness or numbness on one side of the body]]
-* [[Bloody or black stools]]
-* [[Bloody or cloudy urine]]
-== Precautions ==
-Before taking Tenoxicam, it is important to discuss any medical conditions or allergies with a healthcare provider. It is also important to discuss any other medications or supplements being taken, as Tenoxicam can interact with other drugs.
-== See Also ==
-* [[Non-steroidal anti-inflammatory drug]]
 * [[Cyclooxygenase]]
-* [[Prostaglandins]]
+* [[Prostaglandin]]
+* [[Arthritis]]
-[[Category:Drugs]]
-[[Category:Non-steroidal anti-inflammatory drugs]]
-[[Category:Pain management]]
-{{stub}}
+[[Category:Nonsteroidal anti-inflammatory drugs]]